About this Research Topic
Swine are one of the most important food animals worldwide. Vaccines are currently the primary means for the prevention of viral diseases and animal welfare maintenance. However, safe and effective vaccines or alternatives, are still unavailable for many viral diseases of swine. The multiple physiological and anatomical similarities shared with humans permit swine to harbor many zoonotic viruses that are harmful to humans such as influenza A virus and rotaviruses. Understanding how these viruses persist in the host, and how they induce and evade immune responses is highly beneficial to both livestock and biomedical research. Finally, there is also growing interest in how non-bacterial residents of the swine intestinal microbiota, i.e. the virome, may regulate host immunity and also protect against pathogenic viruses. This necessitates gaining a better understanding of swine immune responses to endemic, emerging and zoonotic viruses.
In this Research Topic devoted to anti-viral immune responses in swine, we welcome the submission of Original Research articles with a particular emphasis on novel studies that discuss the mechanism(s) of anti-viral immunity in swine. Submissions on the porcine reproductive disease complex (PRDC), foot and mouth disease virus (FMDV) African swine fever (ASF) and swine influenza (SIV) are encouraged. Novel studies on the gut-mammary gland axis, the fetal immune response to viral infection and the immunological basis for the design of new vaccines and adjuvants to combat porcine enteritis disease virus (PEDV) and other enteric viruses are also of interest. We also welcome immuno-virological studies on emerging viral diseases involving swine. Authors are asked to provide an abstract of their tentative manuscript(s) prior to manuscript submission.
We welcome the submission of articles that address the following sub-topics:
1. Mechanisms of protective immunity to FMDV.
2. Mechanisms of protective immunity to ASF.
3. Mechanisms of protective immunity to SIV.
4. How does PRRSV evade the establishment of sterilizing immunity?
5. In the PRDC, how do multiple viral infections delay or enhance the development of protective immunity to any one virus?
6. How does vaccine design affect the nature and efficacy of immunity to FMDV?
7. The mammary gland-gut axis in passive protection of piglets against PEDV and other enteric viruses.
8. How do porcine viruses cross the placenta and can the fetal immune response provide protection?
9. What mechanisms are activated by modern adjuvants in stimulating protective immunity to viruses in swine?
10. The immune response to emerging viruses in swine reservoirs.
11. How does the embedded virome in swine influence the immune response to pathogenic viruses?
12. Porcine models for basic immunological research.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.