Research Topic

Endocrine Frailty in the Elderly

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About this Research Topic

The senile age is characterized by numerous modifications on the endocrinological level that concern all the main axes. In particular clinical conditions such as: hypogonadism, reduced levels of IGF-1, hypovitaminosis D, osteoporosis, hypothyroidism, sarcopenia, represent frequent problems that require the ...

The senile age is characterized by numerous modifications on the endocrinological level that concern all the main axes. In particular clinical conditions such as: hypogonadism, reduced levels of IGF-1, hypovitaminosis D, osteoporosis, hypothyroidism, sarcopenia, represent frequent problems that require the evaluation of various specialists. Hormonal treatments, mostly substitutive, require the knowledge of precise management rules as well as the knowledge of concrete clinical objectives. In particular, the correct management of sexual activity involves a functional commitment that requires a correct stratification of cardiovascular risk, in particular in consideration of the systemic effects of vasoactive drugs used in the treatment of erectile dysfunction.

The main objective of this Research Topic is to provide a translational vision of geriatric endocrinology that allows the different specialists who interface in the management of patients in the geriatric phase to share a common point of view regarding the endocrinological aspects.

The authors contributing to this Research Topic will illustrate the epidemiological, pathophysiological and clinical aspects of the main hormonal changes that occur in senile age, in such a way that the reader has the possibility to deepen the mechanisms of the various conditions but at the same time has the possibility to obtain information for daily clinical practice regarding the management of these conditions. All topics will be addressed in the form of an article-review. In selected papers, original aspects deriving from clinical and/ or experimental studies underway during the preparation of this collection of articles will be illustrated.

This Research Topic entitled "Endocrine frailty in the Elderly" analyzes, among others, the following aspects related to geriatric endocrinology:
_ Changes of the thyroid function;
_ Changes of the adrenal function;
_ Changes of the somatotropic axis;
_ Changes in metabolic and pancreatic function;
_ Changes in bone function;
_ Changes in sexual function; and
_ Changes in the characteristics of neuroimaging of senescence.


Keywords: Elderly, Aging, Endocrinology, Frailty


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