About this Research Topic
The molecular processes involved in the genesis, differentiation and cell death in the nervous system constitute an area of growing and continuous interest in the neuroscientific community. However, the underlying signal transduction events that participate in the regulation of the above-mentioned events are far from full understanding. An increase number of publications is focused on signal transduction mechanisms that rely on protein cascades, however less information is available about the role and function of lipid signaling cascades. Emerging mechanisms involving lipid signaling and metabolism have been recognized as main modulators in neurobiological processes in nervous system.
Signal transduction processes triggered by bioactive lipids and related transcription factors (immediate early genes, clock proteins, SREBP, metabolic regulators, etc.) have now receiving attention as important nodes for regulating specific cellular processes.
Dysregulation of these lipid-mediated processes may trigger degenerative diseases (Parkinson, Alzheimer, tauopathies, retinopathies) and proliferative disorders (brain cancer, diabetic retinopathy). Moreover, the modern lifestyle (hypercaloric diets, continuous artificial light exposure, sedentary life, shift work, aging, stress, etc.) impacts on lipid signaling and metabolism thus altering brain function, physiology and behavior.
Based on the above-mentioned, the main goal of this Research Topic is to highlight new insights in molecular mechanisms that operate in the nervous system and that could be potential biomarkers or therapeutic targets. Potential topics include but are not limited to the following:
- Lipid signaling in neurobiology processes (development, differentiation and death)
- Oxidative stress, lipid metabolism and signaling in neuronal and glial cells
- Transcription factors modulated by lipid mediators in neurobiological processes
- Circadian regulation and lipid signaling and metabolism in neurons and glia
- Life style, lipid metabolism and brain function and behavior
- Cellular and animal models to study the above-mentioned mechanisms under physiological and pathophysiological conditions
Keywords: biomolecules messengers, cell signaling, cellular stress, ambient factors, neuropathies, behavioral disorders
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