About this Research Topic
Mast cells display heterogeneity in their activity, which depends upon their location and microenvironment. Hence, the mast cell phenotype cannot be generalized and varies depending on location and different pathophysiological conditions, including nociception and degenerative conditions.
New and unexpected functions of mast cells have recently come to light such as their ability to form synapses with dendritic cells and present antigen, as well as mast cell – T cell interactions, especially the ability of the former to increase the numbers of Treg cells playing an anti-inflammatory and immunosuppressive role.
Mast cells have been increasingly involved in conditions involving pain such as fibromyalgia, headache, itch, myalgic encephalomyelitis/chronic fatigue syndrome, sickle cell disease, stroke and traumatic brain injury, thereby attracting greater attention towards their role in pathological conditions.
The aim of this Research Topic is to highlight the current state of knowledge about the involvement of mast cells in critical physiological functions related to the itch, neuroinflammation and pain aiming to identify novel therapeutic targets for multiple disorders.
Keywords: Mast cells, pain, itch, neurodegeneration, neuroinflammation
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