The world according to zebrafish: How neural circuits generate behaviour

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Editorial

30 July 2014

The world according to zebrafish: how neural circuits generate behavior

Germán Sumbre

and

Gonzalo G. de Polavieja

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27 citations

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2

École Normale Supérieure

Gonzalo G. De Polavieja

Champalimaud Foundation

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Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology, mathematics and using tractable model systems.

The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for combining state-of-the-art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism.

Furthermore, the zebrafish model offers a large and increasing collection of mutant and transgenic lines, some of them modelling human brain diseases.

With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.

Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology, mathematics and using tractable model systems.

The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for combining state-of-the-art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism.

Furthermore, the zebrafish model offers a large and increasing collection of mutant and transgenic lines, some of them modelling human brain diseases.

With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.

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Editors

École Normale Supérieure

Gonzalo G. De Polavieja

Champalimaud Foundation

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Frontiers in Neural Circuits

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