Research Topic

Regulation of Dynamic Changes and Remodeling Events During the Formation, Rescue and Regression of the Corpus Luteum

About this Research Topic

In spite of many studies we are still far from understanding the key molecular mechanisms responsible for the proper regulation of the fascinating series of events occurring during the folliculo-luteal transition and formation, rescue or regression of the corpus luteum. Nor do we have sufficient insights into effects of environmental and metabolic factors that can interfere with these events, thus possibly leading to sub- or infertility or problems of modern assisted reproduction. In addition, corpus luteum formation and regression also represent excellent experimental models to study molecular processes of cellular development, differentiation, cell survival and cell death in general.

In particular the folliculo-luteal transition is a highly dynamic process including a phase of epithelial-mesenchymal-transition (EMT), which gives rise to subsequent developmental steps from the early to mature corpus luteum followed by luteolysis or persistence, which in most species is essential to maintain pregnancy. The mature corpora luteum is a highly active endocrine gland and part of the complex network regulating the female reproductive cycle.

Throughout all these stages finely tuned sequences of molecular, physiological and morphological changes, progressive angiogenesis and intricate intercellular communications between the different cellular components of the corpus luteum are essential. Also the infiltration of immune cells plays an important, but still insufficiently studied role, and is essential in both the development and later rescue or regression of the corpus luteum.

The objective of this Research Topic is to share, disseminate and discuss scientific knowledge and novel ideas on key regulatory events occurring during the folliculo-luteal transition, formation, survival and regression of the corpus luteum in different vertebrate species. This will lead to new insights into the complex molecular events that are involved in these processes and ultimately to a greater understanding of the normal physiology, but also insufficiencies occurring during the luteal phase.

Covering the above aspects, informative experimental approaches including novel tissue culture and animal models are highly welcome to shed light upon normal, but also impaired mechanisms of regulation underlying sub- and infertility. Reviews, original research articles, commentaries and hypotheses promoting our understanding are invited under this topic.


Keywords: follicle, corpus luteum, angiogenesis, steroidogenesis, regression


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

In spite of many studies we are still far from understanding the key molecular mechanisms responsible for the proper regulation of the fascinating series of events occurring during the folliculo-luteal transition and formation, rescue or regression of the corpus luteum. Nor do we have sufficient insights into effects of environmental and metabolic factors that can interfere with these events, thus possibly leading to sub- or infertility or problems of modern assisted reproduction. In addition, corpus luteum formation and regression also represent excellent experimental models to study molecular processes of cellular development, differentiation, cell survival and cell death in general.

In particular the folliculo-luteal transition is a highly dynamic process including a phase of epithelial-mesenchymal-transition (EMT), which gives rise to subsequent developmental steps from the early to mature corpus luteum followed by luteolysis or persistence, which in most species is essential to maintain pregnancy. The mature corpora luteum is a highly active endocrine gland and part of the complex network regulating the female reproductive cycle.

Throughout all these stages finely tuned sequences of molecular, physiological and morphological changes, progressive angiogenesis and intricate intercellular communications between the different cellular components of the corpus luteum are essential. Also the infiltration of immune cells plays an important, but still insufficiently studied role, and is essential in both the development and later rescue or regression of the corpus luteum.

The objective of this Research Topic is to share, disseminate and discuss scientific knowledge and novel ideas on key regulatory events occurring during the folliculo-luteal transition, formation, survival and regression of the corpus luteum in different vertebrate species. This will lead to new insights into the complex molecular events that are involved in these processes and ultimately to a greater understanding of the normal physiology, but also insufficiencies occurring during the luteal phase.

Covering the above aspects, informative experimental approaches including novel tissue culture and animal models are highly welcome to shed light upon normal, but also impaired mechanisms of regulation underlying sub- and infertility. Reviews, original research articles, commentaries and hypotheses promoting our understanding are invited under this topic.


Keywords: follicle, corpus luteum, angiogenesis, steroidogenesis, regression


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

29 March 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

29 March 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top
);