Research Topic

Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions

About this Research Topic

There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form.

While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment.

In this Research Topic, we will provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases. The manuscripts should focus on pathophysiology, epidemiology, diagnosis and treatment of vitamin D deficiency and other vitamin D related metabolic disorders.

Original research or review articles about DBP and/or total and free vitamin D levels in different physiological and pathophysiological conditions are welcome.


Keywords: 25 OH Vitamin D, DBP, Free vitamin D, Hormone, Diagnosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form.

While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment.

In this Research Topic, we will provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases. The manuscripts should focus on pathophysiology, epidemiology, diagnosis and treatment of vitamin D deficiency and other vitamin D related metabolic disorders.

Original research or review articles about DBP and/or total and free vitamin D levels in different physiological and pathophysiological conditions are welcome.


Keywords: 25 OH Vitamin D, DBP, Free vitamin D, Hormone, Diagnosis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 January 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 January 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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