About this Research Topic
There are several challenges for validating novel biomarkers for NDDs. First, many potential biomarkers change with development; thus, it will be critical to understand the developmental trajectories of these measures to apply them in a trials context. Second, the neurodevelopmental disorders under consideration are primarily rare genetic diseases. Therefore, limited patient populations will likely require multi-site clinical biomarker studies, which increases the need for rigorous data/acquisition standards, portability, feasibility, and reproducibility across sites. Third, there is a need to understand the fundamental biology underlying these markers and how these biomarkers correlate with disease onset, severity and/or response to treatment, and how similar these mechanisms and effects are to those in animal models. Multi-disciplinary efforts that encompass investigators with basic neuroscience, genetics, imaging, electrophysiology, data science and clinical trial expertise may be necessary to overcome these challenges.
In this Research Topic, we will highlight basic, translational and clinical research studies that investigate a broad range of biomarkers with potential utility for translational drug development programs for neurodevelopmental disorders across the life span.
Keywords: autism, clinical trials, EEG, MRI, imaging
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