About this Research Topic
An increasing body of evidence shows that "inflammatory mechanisms" cause and promote many diseases, including, cardiovascular and cancer. Inflammation is a physiological host response to tissue damage with the primary purpose of restoring tissue homeostasis. It is now well-known that the effective resolution of inflammation is a dynamic process regulated through several cellular responses to endogenously generated mediators. If acute inflammation is uncontrolled or unresolved, it progresses to the development of chronic inflammation that promotes tissue damage and the development fibrosis, eventually leading to loss of organ function. Also, a chronic inflammatory state is a risk factor for cancer development.
This Research Topic has the objective to clarify the molecular, cellular and genetic determinants which promote the development and progression of inflammation and to describe possible therapeutic strategies to mitigate or prevent it. The role of novel mediators involved in the inflammatory response and its resolution, including the microRNAs, and lipids will be described. All this new information will permit to develop innovative approaches for the treatment of cardiovascular disease and cancer. Finally, novel biomarkers will be useful for an early diagnosis and the development of a personalized approach in the treatment of inflammation-related diseases.
These issues were addressed at the International Meeting entitled "Resolution of inflammation: mechanisms, mediators and & biomarkres" (November 13-17, 2018, Pescara, Italy), organized by Paola Patrignani, Bernhard Brüne, Dieter Steinhilber. The speakers of the meeting will contribute to this Research Topic by submitting an original work or a review.
Keywords: inflammation, resolution, biomarkers
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