About this Research Topic
The brain is a critical organ with high plasticity potential. The plasticity potential is correlated with multiple physiological processes, such as formation and consolidation of memory, circadian clock, as well as endocrine and immunoreaction. In stroke and trauma, the neural networks are broken, and the brain initiates the reparative process and attempts to reconstruct them. However, this process is insufficient and limited by many factors. A thorough clarification of the cellular and molecular mechanisms of plasticity in brain injury and of the neural networks reconstruction is a necessary endeavor in the search for new therapeutic targets for brain injury.
The reconstruction of the neural network is the ultimate purpose of the treatment for brain injury, such as stroke, trauma, cerebral palsy, neurodegenerative disorder, et al. The plasticity in brain injury is different from regeneration of the spinal cord in spinal cord injury: it occurs in a complex environment that includes neural stem cells, injured neurons (surviving bodies and dead axons or synapses), denervated intact neurons and glia, et al. The regenerative process includes endogenous neurogenesis, axon regeneration, myelination, and synaptogenesis. This Research Topic is devoted to the cellular and molecular mechanisms of plasticity in brain injury, and to meaningful exploration for the promotion of neural plasticity following brain injury.
Surrounding this Research Topic “Plasticity and Reconstruction of Neural Networks in Brain Injury”, we will welcome high-quality contributions from excellent neuroscientists worldwide on basic research and clinical studies. These manuscripts can be original research articles, minireviews, reviews, comments, meta-analyses, case report and can cover the following areas:
- The detection method of brain plasticity, such as imaging and tracer technique,
- Cellular and molecular mechanisms,
- Factors involved in the neural plasticity,
- Interventional strategies promoting this process.
Keywords: stroke, trauma, plasticity, reconstruction of neural network, synaptogenesis