Research Topic

Advances in the Endocrine Role of the Skeleton

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About this Research Topic

Bone is a dynamic connective tissue subjected to a continuous remodeling based on resorption and formation activities. This process is regulated by a tight cross-talk between bone cells, osteoclasts, osteoblasts and osteocytes.

Bone remodeling is crucial for bone homeostasis, skeleton integrity and ...

Bone is a dynamic connective tissue subjected to a continuous remodeling based on resorption and formation activities. This process is regulated by a tight cross-talk between bone cells, osteoclasts, osteoblasts and osteocytes.

Bone remodeling is crucial for bone homeostasis, skeleton integrity and mechanical properties. However, in the last 10 years the understanding of the endocrine actions of the skeleton through mouse models and human genetic disorders has revealed new functions associated with whole body physiology.

Indeed, bone functionally interacts with many other organs and tissues such as bone marrow, kidney, adipose tissue, pancreas, brain and gonads. Since it is now well established that secreted factors, including osteocalcin and lipocalin 2, are key regulators of these interactions, they could become pharmacological targets in the treatment of many metabolic diseases, including diabetes and obesity.

We welcome investigators to contribute original research articles as well as review articles that will describe the endocrine role of the skeleton, pathological conditions, and innovative treatments for bone and metabolic diseases.

Potential topics include, but are not limited to articles describing the interplay between the following:

- Bone and kidney
- Bone and adipose tissue
- Bone and glucose metabolism
- Bone and male fertility
- Bone and appetite regulation
- Bone and cognition regulation


Keywords: Bone, Endocrine, Osteoclast, Osteoblast, Osteocyte


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