One of the most entrenched tenets of research in neuroscience is that the adult brain has limited capability for endogenous regenerative capacity. However, over the last few decades, this scientific dogma has been overturned by the discovery and functional elucidation of how neural stem cells function in the adult mammalian brain. The seminal discovery of adult neurogenesis has generated enormous interest and excitement because of the potential for the development of innovative regenerative strategies for repair across many brain diseases.
The hippocampus is a crucial brain structure important for memory processing and emotional regulation. Significant evidence establishes adult hippocampal neurogenesis within the dentate gyrus (DG), as the process in which adult-born neurons develop from neural stem cells (NSCs) and play an integral role in spatial learning, pattern separation, and emotional regulation in physiological conditions that are impaired by brain disease. In addition, the potential impact of the proliferative response of stem cells that develop into adult-born neurons to remodel brain circuits following brain damage is paramount to advance our understanding of brain repair. Thus, one pinnacle that the regenerative scientific community strives to achieve is to mechanistically unveil how newly generated neurons contribute to protect the brain’s complex functional structures and their inherent interactions during neurological, neurodegenerative, neuropsychiatric and physical damage. Our collective effort is important to critically understand precise mechanisms of adult-born neurons that facilitates functional repair and engage in recovery from brain insults, thus providing improved quality of life to people suffering from brain diseases.
This Research Topic aims to provide and discuss the latest evidence regarding disease-mediated neural regenerative perturbations and the promotion of neuroprotective responses potentiated by adult neurogenesis using cellular techniques, rodent models, induced pluripotent stem cells (iPSCs) and brain organoid systems, and their implication in a broad spectrum of neural injury and brain diseases. This topic aims to provide cutting edge techniques and the latest discoveries of novel targets that are mechanistically implicated in the stimulation of the brain’s neurogenic capability diseases that affect adults. Moreover, this topic will provide the scientific community with novel innovative strategies implemented in animal models and translational clinical research to enhance neurogenesis with the effort of counteracting neurological, cognitive and emotional impairments. Therefore, this topic’s final aim is to critically evaluate, through research and dissemination of this knowledge, how adult neurogenesis will be a frontline tool to attenuate or prevent brain disorders.
Submissions are welcome for the following article types: original research, review, mini-reviews, research protocol/method, opinion and hypothesis.
One of the most entrenched tenets of research in neuroscience is that the adult brain has limited capability for endogenous regenerative capacity. However, over the last few decades, this scientific dogma has been overturned by the discovery and functional elucidation of how neural stem cells function in the adult mammalian brain. The seminal discovery of adult neurogenesis has generated enormous interest and excitement because of the potential for the development of innovative regenerative strategies for repair across many brain diseases.
The hippocampus is a crucial brain structure important for memory processing and emotional regulation. Significant evidence establishes adult hippocampal neurogenesis within the dentate gyrus (DG), as the process in which adult-born neurons develop from neural stem cells (NSCs) and play an integral role in spatial learning, pattern separation, and emotional regulation in physiological conditions that are impaired by brain disease. In addition, the potential impact of the proliferative response of stem cells that develop into adult-born neurons to remodel brain circuits following brain damage is paramount to advance our understanding of brain repair. Thus, one pinnacle that the regenerative scientific community strives to achieve is to mechanistically unveil how newly generated neurons contribute to protect the brain’s complex functional structures and their inherent interactions during neurological, neurodegenerative, neuropsychiatric and physical damage. Our collective effort is important to critically understand precise mechanisms of adult-born neurons that facilitates functional repair and engage in recovery from brain insults, thus providing improved quality of life to people suffering from brain diseases.
This Research Topic aims to provide and discuss the latest evidence regarding disease-mediated neural regenerative perturbations and the promotion of neuroprotective responses potentiated by adult neurogenesis using cellular techniques, rodent models, induced pluripotent stem cells (iPSCs) and brain organoid systems, and their implication in a broad spectrum of neural injury and brain diseases. This topic aims to provide cutting edge techniques and the latest discoveries of novel targets that are mechanistically implicated in the stimulation of the brain’s neurogenic capability diseases that affect adults. Moreover, this topic will provide the scientific community with novel innovative strategies implemented in animal models and translational clinical research to enhance neurogenesis with the effort of counteracting neurological, cognitive and emotional impairments. Therefore, this topic’s final aim is to critically evaluate, through research and dissemination of this knowledge, how adult neurogenesis will be a frontline tool to attenuate or prevent brain disorders.
Submissions are welcome for the following article types: original research, review, mini-reviews, research protocol/method, opinion and hypothesis.
