Reactive Oxygen Species (ROS) have been described as a physiological second messenger in a narrow range of concentrations, while higher concentrations cause acute or chronic oxidative stress in cells. Thus, the simple and complete inhibition of ROS production throughout the administration of broad spectrum antioxidants has been revealed as ineffective, if not toxic, during the therapeutic approach of a large series of chronic diseases. On the contrary, ozone, when in contact with the human tissues, acts as an endogenous redox modulator by reducing the oxidative stress via activation of Nrf2/ARE system in cells, preserving the ROS pivotal role in important signaling pathways.
Moreover, ozone also exerts an anti-inflammatory and analgesic actions suggesting a cross-talk between oxidative stress, inflammation and pain at molecular and pathophysiological level in human tissues.
The goal of this Research Topic is to offer a comprehensive picture of the new research evidences in ozone therapy from bench to bedside.
This Research Topic will contain short reports, original research, and review manuscripts addressing all biochemical, physiological, and clinical aspects of the ozone applications in medicine. Original research articles can be on any topic related to: Nrf2 modulation from ozone, interdependence of the anti-inflammatory, antioxidant and analgesic actions during ozone therapy, experimental, and clinical evidence of the therapeutic effects of ozone in acute and chronic diseases.
Review manuscripts should debate the molecular and physiological background of their topic, opening a discussion on the possible translation of this basic research into clinical setting.
The scope of this Research Topic will be to obtain reviews and original research dealing with the biochemical and pathophysiological aspect of the use of ozone in a broad spectrum of diseases.
This Research Topic should be able to collect the most relevant knowledge on the molecular and physiological mechanisms of actions of the ozone in medicine and its potential role as integrative therapy for acute and chronic diseases.
Short reports, full articles, and reviews about molecular and physiological adaptive changes induced by ozone in different tissues are welcome.
Reactive Oxygen Species (ROS) have been described as a physiological second messenger in a narrow range of concentrations, while higher concentrations cause acute or chronic oxidative stress in cells. Thus, the simple and complete inhibition of ROS production throughout the administration of broad spectrum antioxidants has been revealed as ineffective, if not toxic, during the therapeutic approach of a large series of chronic diseases. On the contrary, ozone, when in contact with the human tissues, acts as an endogenous redox modulator by reducing the oxidative stress via activation of Nrf2/ARE system in cells, preserving the ROS pivotal role in important signaling pathways.
Moreover, ozone also exerts an anti-inflammatory and analgesic actions suggesting a cross-talk between oxidative stress, inflammation and pain at molecular and pathophysiological level in human tissues.
The goal of this Research Topic is to offer a comprehensive picture of the new research evidences in ozone therapy from bench to bedside.
This Research Topic will contain short reports, original research, and review manuscripts addressing all biochemical, physiological, and clinical aspects of the ozone applications in medicine. Original research articles can be on any topic related to: Nrf2 modulation from ozone, interdependence of the anti-inflammatory, antioxidant and analgesic actions during ozone therapy, experimental, and clinical evidence of the therapeutic effects of ozone in acute and chronic diseases.
Review manuscripts should debate the molecular and physiological background of their topic, opening a discussion on the possible translation of this basic research into clinical setting.
The scope of this Research Topic will be to obtain reviews and original research dealing with the biochemical and pathophysiological aspect of the use of ozone in a broad spectrum of diseases.
This Research Topic should be able to collect the most relevant knowledge on the molecular and physiological mechanisms of actions of the ozone in medicine and its potential role as integrative therapy for acute and chronic diseases.
Short reports, full articles, and reviews about molecular and physiological adaptive changes induced by ozone in different tissues are welcome.
