There is a current paradox in physiological and pathophysiological research in nephrology. On the one hand, renal replacement therapy in form of hemodialysis, peritoneal dialysis, and transplantation is an established life-saving treatment all around the world. Consequently, translational kidney research virtually became a victim of its success. On the other hand, Chronic Kidney Disease (CKD) leading to irreversible organ failure is steadily growing as a global burden to the health care system and society. Thus, a special focus on kidney research with an emphasis on renal protection and regeneration is increasingly necessary. Several essential aspects of this scientific area such as the description of local stem cells niches in vascular, tubular, and interstitial compartments of the adult kidney or novel renoprotective therapies have been intensively developing in the last years. However, kidney regeneration in terms of building new nephrons after the end of nephrogenesis remains a future goal.
The Frontiers in Physiology Research Topic collection “Recent advances on renoprotection and kidney regeneration” aims to bring together recent findings thus filling gaps of knowledge, highlighting the latest progress in the field, and expanding the interest in the research community.
This Research Topic will feature interdisciplinary advances in cell biology, physiology, pathophysiology, pharmacology, and medicine with regard to kidney protection and regeneration spanning from basic research to clinical studies.
We welcome Original Research, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory, Perspective, Case Report, Conceptual Analysis, Data Report, Brief Research Report, Opinion, and Technology and Code submissions that focus, but are not limited to, the following themes:
1. Focus on the renal vasculature
- Protection and regeneration of the glomerulus
- Protection and regeneration of the renal peritubular microvasculature: role of micro-endothelium and pericytes
- Protection and regeneration of the large renal vessels
2. Focus on the tubular system
- Protection and regeneration of the proximal tubule
- Role of macula densa in renoprotection and kidney regeneration
- Role of collecting duct in renoprotection and kidney regeneration
- SGLT2 inhibition as renoprotective therapy
3. Focus on the role of the interstitium in kidney regeneration and renoprotection
There is a current paradox in physiological and pathophysiological research in nephrology. On the one hand, renal replacement therapy in form of hemodialysis, peritoneal dialysis, and transplantation is an established life-saving treatment all around the world. Consequently, translational kidney research virtually became a victim of its success. On the other hand, Chronic Kidney Disease (CKD) leading to irreversible organ failure is steadily growing as a global burden to the health care system and society. Thus, a special focus on kidney research with an emphasis on renal protection and regeneration is increasingly necessary. Several essential aspects of this scientific area such as the description of local stem cells niches in vascular, tubular, and interstitial compartments of the adult kidney or novel renoprotective therapies have been intensively developing in the last years. However, kidney regeneration in terms of building new nephrons after the end of nephrogenesis remains a future goal.
The Frontiers in Physiology Research Topic collection “Recent advances on renoprotection and kidney regeneration” aims to bring together recent findings thus filling gaps of knowledge, highlighting the latest progress in the field, and expanding the interest in the research community.
This Research Topic will feature interdisciplinary advances in cell biology, physiology, pathophysiology, pharmacology, and medicine with regard to kidney protection and regeneration spanning from basic research to clinical studies.
We welcome Original Research, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory, Perspective, Case Report, Conceptual Analysis, Data Report, Brief Research Report, Opinion, and Technology and Code submissions that focus, but are not limited to, the following themes:
1. Focus on the renal vasculature
- Protection and regeneration of the glomerulus
- Protection and regeneration of the renal peritubular microvasculature: role of micro-endothelium and pericytes
- Protection and regeneration of the large renal vessels
2. Focus on the tubular system
- Protection and regeneration of the proximal tubule
- Role of macula densa in renoprotection and kidney regeneration
- Role of collecting duct in renoprotection and kidney regeneration
- SGLT2 inhibition as renoprotective therapy
3. Focus on the role of the interstitium in kidney regeneration and renoprotection
