Bones play essential functions throughout our lives. No matter their shapes or sizes, bones support our body, protect organs and tissues, store calcium and fat, and produce blood cells. Bones are formed by the process of either intramembranous or endochondral ossification. After their formation, bones keep modelling and remodelling throughout life. However, ageing, tumors, fractures, and inflammation can cause bone loss, severely influencing our health or life. Thus, the regeneration of lost bones is of great importance.
To produce healthy bones, i.e. bones similar in quantity and quality to those of the host, researchers should understand the physiological and pathological microenvironment of the bones, including the role of osteoblasts, osteoclasts, osteocytes and their interactions, as well as the role of molecules from the endocrine system and blood circulation, among others. Therefore, the processes and regulations of bone development and bone homeostasis are essential, and the theories can be used for bone regeneration.
The scope of this topic covers the characteristics and functions of bone-associated cells, including bone marrow mesenchymal stem cells, haematopoietic stem cells, osteoblasts, osteoclasts and osteocytes, which are involved in the development, maintenance, remodelling and regeneration of bone.
We welcome Original Research Articles, Brief Research Reports, Reviews, Mini Reviews, and Perspectives on the following (or related) research areas:
• Identification and characterization of bone marrow cells;
• Molecular regulations of bone-related cells;
• Crosstalk among bone-related cells, and bone marrow cells, as well as immune cells;
• Bone regeneration is based on the theories above.
Bones play essential functions throughout our lives. No matter their shapes or sizes, bones support our body, protect organs and tissues, store calcium and fat, and produce blood cells. Bones are formed by the process of either intramembranous or endochondral ossification. After their formation, bones keep modelling and remodelling throughout life. However, ageing, tumors, fractures, and inflammation can cause bone loss, severely influencing our health or life. Thus, the regeneration of lost bones is of great importance.
To produce healthy bones, i.e. bones similar in quantity and quality to those of the host, researchers should understand the physiological and pathological microenvironment of the bones, including the role of osteoblasts, osteoclasts, osteocytes and their interactions, as well as the role of molecules from the endocrine system and blood circulation, among others. Therefore, the processes and regulations of bone development and bone homeostasis are essential, and the theories can be used for bone regeneration.
The scope of this topic covers the characteristics and functions of bone-associated cells, including bone marrow mesenchymal stem cells, haematopoietic stem cells, osteoblasts, osteoclasts and osteocytes, which are involved in the development, maintenance, remodelling and regeneration of bone.
We welcome Original Research Articles, Brief Research Reports, Reviews, Mini Reviews, and Perspectives on the following (or related) research areas:
• Identification and characterization of bone marrow cells;
• Molecular regulations of bone-related cells;
• Crosstalk among bone-related cells, and bone marrow cells, as well as immune cells;
• Bone regeneration is based on the theories above.