Since the discovery of penicillin, the first antibiotic in the modern era, the treatment of diseases that were once considered the wrath of gods became possible. Along with this remarkable human stride came a new challenge, antimicrobial resistance. As scientists continue to develop new medications to eliminate pathogens and treat infectious diseases, these pathogens fight back and evolve to evade the effect of these medications. Difficult to treat infections caused by multi-drug resistant organisms are a challenge to health care practitioners, a financial burden to health care systems, and above all are associated with poor clinical outcomes. Research is required to bridge the gaps in all aspects of drug discovery, clinical use, and antimicrobial stewardship. This research will provide effective treatment options, inform clinicians, and guide decision-making. We propose this Research Topic to attract authors interested in these fields of knowledge.
The dwindling interest in investing in antimicrobial research coupled with the growing rate of antimicrobial resistance necessitates global understanding of the appropriate use of antimicrobials, exploring diverse synergistic combinations, repurposing existing antimicrobial agents, evaluating best practices to halt the development of resistance and optimizing clinical outcomes. The goal is to encourage research efforts that further our knowledge of these topics and add to the scientific literature that promotes evidence-based practices in the field of medical microbiology and infectious diseases. Fostering the awareness of the medical community along with educating the public and alerting organizational policymakers to the amplifying menace posed by difficult to treat infections; all are critical to protect public health.
This Research Topic aims to publish research articles related to exploring the safety and efficacy of antimicrobials or antimicrobial combinations against various pathogenic micro-organisms in different settings as well as a demonstration of resistance development and mechanisms. In addition, research describing the development of novel antimicrobials, alternative therapies, and innovative pharmaceutical formulations to enhance efficacy, eliminate toxicity or mitigate resistance is welcome.
The scope encompasses research projects utilizing in-vitro dynamic models, animal models of infection with controlled antimicrobial exposure, various benchtop phenotypic and genotypic molecular biology studies. Finally, clinical trials (phases I, II and III), robust case series, systematic reviews and meta-analyses that contribute to improving clinical practice and patient care will be considered.
Since the discovery of penicillin, the first antibiotic in the modern era, the treatment of diseases that were once considered the wrath of gods became possible. Along with this remarkable human stride came a new challenge, antimicrobial resistance. As scientists continue to develop new medications to eliminate pathogens and treat infectious diseases, these pathogens fight back and evolve to evade the effect of these medications. Difficult to treat infections caused by multi-drug resistant organisms are a challenge to health care practitioners, a financial burden to health care systems, and above all are associated with poor clinical outcomes. Research is required to bridge the gaps in all aspects of drug discovery, clinical use, and antimicrobial stewardship. This research will provide effective treatment options, inform clinicians, and guide decision-making. We propose this Research Topic to attract authors interested in these fields of knowledge.
The dwindling interest in investing in antimicrobial research coupled with the growing rate of antimicrobial resistance necessitates global understanding of the appropriate use of antimicrobials, exploring diverse synergistic combinations, repurposing existing antimicrobial agents, evaluating best practices to halt the development of resistance and optimizing clinical outcomes. The goal is to encourage research efforts that further our knowledge of these topics and add to the scientific literature that promotes evidence-based practices in the field of medical microbiology and infectious diseases. Fostering the awareness of the medical community along with educating the public and alerting organizational policymakers to the amplifying menace posed by difficult to treat infections; all are critical to protect public health.
This Research Topic aims to publish research articles related to exploring the safety and efficacy of antimicrobials or antimicrobial combinations against various pathogenic micro-organisms in different settings as well as a demonstration of resistance development and mechanisms. In addition, research describing the development of novel antimicrobials, alternative therapies, and innovative pharmaceutical formulations to enhance efficacy, eliminate toxicity or mitigate resistance is welcome.
The scope encompasses research projects utilizing in-vitro dynamic models, animal models of infection with controlled antimicrobial exposure, various benchtop phenotypic and genotypic molecular biology studies. Finally, clinical trials (phases I, II and III), robust case series, systematic reviews and meta-analyses that contribute to improving clinical practice and patient care will be considered.
