Epigenetic mechanisms are dynamic processes during life that control gene expression and cellular function, independent of the genomic DNA sequences. Such mechanisms dictate the cellular identity, as well as cell type-specific morphology and function. Accordingly, epigenetic mechanisms control stem cell fate commitment at different stages of development and their deregulation leads to human disease. Recent advances in molecular, cellular, and stem cell biology have highlighted the role of epigenetics and epigenetic factors in cellular function and metabolism through the activity of mediator factors and their crosstalk with cell signalling molecules. In this regard, genetic mutation and/or altered expression of the three types of epigenetic modulators, "Writers, Readers, and Erasers," are associated with developmental disorders and human disease. These regulatory mechanisms act at different biological levels that may include transcriptional, post-transcriptional, and translational levels. Subsequently, the activity of cell signalling molecules may impact fundamental cellular function and post-translational mechanisms linking epigenetics to protein post-translational modifications.
In the first volume of this Research Topic, we gathered a collection of original research and review articles providing insights on the role of epigenetic mechanisms including histone post-translational modifications, DNA methylation, chromatin remodelling complexes, and non-coding regulatory RNA molecules in rare diseases.
Epigenetic research is advancing at an incredible pace with new findings and reports every single day. We are now inviting further manuscripts that would address recent discoveries on epigenetic mechanisms and epigenetic factors that control fundamental developmental processes impacting cellular function and/or metabolism and signalling pathways highlighting their impact on health and disease conditions with a clear focus on rare disorders.
With this volume II Research Topic, we aim to build on the progress demonstrated in the first volume. We hope to gather complementary original research and review articles that would address different aspects of epigenetic regulation. Studies that cover different cellular and animal model systems and patient-derived discoveries are also welcome. This collection is expected to provide a better understanding of the cellular biology and mechanism of disease, providing important insight into the translation of basic science into therapeutic strategies for rare human diseases.
Epigenetic mechanisms are dynamic processes during life that control gene expression and cellular function, independent of the genomic DNA sequences. Such mechanisms dictate the cellular identity, as well as cell type-specific morphology and function. Accordingly, epigenetic mechanisms control stem cell fate commitment at different stages of development and their deregulation leads to human disease. Recent advances in molecular, cellular, and stem cell biology have highlighted the role of epigenetics and epigenetic factors in cellular function and metabolism through the activity of mediator factors and their crosstalk with cell signalling molecules. In this regard, genetic mutation and/or altered expression of the three types of epigenetic modulators, "Writers, Readers, and Erasers," are associated with developmental disorders and human disease. These regulatory mechanisms act at different biological levels that may include transcriptional, post-transcriptional, and translational levels. Subsequently, the activity of cell signalling molecules may impact fundamental cellular function and post-translational mechanisms linking epigenetics to protein post-translational modifications.
In the first volume of this Research Topic, we gathered a collection of original research and review articles providing insights on the role of epigenetic mechanisms including histone post-translational modifications, DNA methylation, chromatin remodelling complexes, and non-coding regulatory RNA molecules in rare diseases.
Epigenetic research is advancing at an incredible pace with new findings and reports every single day. We are now inviting further manuscripts that would address recent discoveries on epigenetic mechanisms and epigenetic factors that control fundamental developmental processes impacting cellular function and/or metabolism and signalling pathways highlighting their impact on health and disease conditions with a clear focus on rare disorders.
With this volume II Research Topic, we aim to build on the progress demonstrated in the first volume. We hope to gather complementary original research and review articles that would address different aspects of epigenetic regulation. Studies that cover different cellular and animal model systems and patient-derived discoveries are also welcome. This collection is expected to provide a better understanding of the cellular biology and mechanism of disease, providing important insight into the translation of basic science into therapeutic strategies for rare human diseases.