Pharmacometrics represents a strategy to optimize and rationalize decision-making process integrating information on drug behavior, pharmacological response, and disease progression both in the drug development phases and in their clinical use. Pharmacometrics focuses on characterizing the pharmacokinetic and pharmacodynamic behavior of one or several active ingredients through the development of mathematical and statistical models that allow characterizing both the average behavior in the population and the different sources of variability. Currently, pharmacometrics has transformed drug development and therapeutic use paradigm, which yield to the recognition by the main regulatory agencies (FDA, EMA, and PMDA).
This Research Topic of Frontiers in Pharmacology will serve to highlight the relevance of pharmacometrics on new modeling methodologies in medicines development, individualized precision dosing strategies and translational knowledge generation to support new drug candidates.
The Research Topic intends to show examples of the use of pharmacometrics at the preclinical or clinical level in different therapeutic areas characterizing the PK or PK/PD properties, integrating the available information for the optimal selection of treatments in sub-groups of the population, as well as mechanistic models (QSP) that allow the identification of new therapeutic targets and/or understanding of complex biological systems.
Pharmacometrics represents a strategy to optimize and rationalize decision-making process integrating information on drug behavior, pharmacological response, and disease progression both in the drug development phases and in their clinical use. Pharmacometrics focuses on characterizing the pharmacokinetic and pharmacodynamic behavior of one or several active ingredients through the development of mathematical and statistical models that allow characterizing both the average behavior in the population and the different sources of variability. Currently, pharmacometrics has transformed drug development and therapeutic use paradigm, which yield to the recognition by the main regulatory agencies (FDA, EMA, and PMDA).
This Research Topic of Frontiers in Pharmacology will serve to highlight the relevance of pharmacometrics on new modeling methodologies in medicines development, individualized precision dosing strategies and translational knowledge generation to support new drug candidates.
The Research Topic intends to show examples of the use of pharmacometrics at the preclinical or clinical level in different therapeutic areas characterizing the PK or PK/PD properties, integrating the available information for the optimal selection of treatments in sub-groups of the population, as well as mechanistic models (QSP) that allow the identification of new therapeutic targets and/or understanding of complex biological systems.
