One of the most commonly diagnosed cancers is breast cancer, which is the second leading cause of death in women. Despite significant advances in breast cancer treatment, there is still a lack of early detection and, more importantly, effective treatment. Exosomes are nanosized extracellular vesicles produced by various cells with the size range of 50-150 and are commonly found in body fluids. The major function of exosomes is related to intracellular communication. Since exosomes package the contents of donor cells, they can be used as detection tools and biomarkers for diseases, especially cancer.
Circulating exosomal microRNAs (miRs) are one of the major cargoes (miRNAs) that play an essential role in breast cancer metastasis. Endogenous non-coding RNAs are small, ~21-23 nucleotides (nt), and have a regulatory function in gene expression, cancer proliferation, growth and metastasis. The miRs can be packaged into exosomes and released by tumor cells into the tumor microenvironment to promote breast cancer metastasis. There is another category of non-coding RNAs which are >200 nt are known as lncRNAs, these also have been found to be associated with different malignancies including breast cancer.
This research topic aims to present recent studies in exosome and miRNA biogenesis, cargo sorting in exosomes, and exosomal miRNAs that have been reported to regulate breast cancer invasion, metastasis, and anticancer drug resistance. We Welcome submissions that not only address advanced new diagnostic and therapeutic methods for breast cancer patients that target exosomal miRNAs, but also submissions which cover the role of tumor-derived exosomal miRNAs in the development and reprogramming of the tumor microenvironment.
We encourage authors to submit original research, systematic reviews, and review articles that address miRNA/lncRNA profiling, their role in breast cancer diagnosis and prognosis as biomarkers, and techniques using exosomal miRNAs/lncRNAs to prevent cancer proliferation as a therapeutic intervention, including but not limited to the following topics.
- Exosomal microRNAs/lncRNAs for breast cancer treatment
- Exosomal microRNAs/lncRNAs as biomarkers for breast cancer diagnosis and prognosis
- Targeted exosomes as microRNA/lncRNAs carriers
One of the most commonly diagnosed cancers is breast cancer, which is the second leading cause of death in women. Despite significant advances in breast cancer treatment, there is still a lack of early detection and, more importantly, effective treatment. Exosomes are nanosized extracellular vesicles produced by various cells with the size range of 50-150 and are commonly found in body fluids. The major function of exosomes is related to intracellular communication. Since exosomes package the contents of donor cells, they can be used as detection tools and biomarkers for diseases, especially cancer.
Circulating exosomal microRNAs (miRs) are one of the major cargoes (miRNAs) that play an essential role in breast cancer metastasis. Endogenous non-coding RNAs are small, ~21-23 nucleotides (nt), and have a regulatory function in gene expression, cancer proliferation, growth and metastasis. The miRs can be packaged into exosomes and released by tumor cells into the tumor microenvironment to promote breast cancer metastasis. There is another category of non-coding RNAs which are >200 nt are known as lncRNAs, these also have been found to be associated with different malignancies including breast cancer.
This research topic aims to present recent studies in exosome and miRNA biogenesis, cargo sorting in exosomes, and exosomal miRNAs that have been reported to regulate breast cancer invasion, metastasis, and anticancer drug resistance. We Welcome submissions that not only address advanced new diagnostic and therapeutic methods for breast cancer patients that target exosomal miRNAs, but also submissions which cover the role of tumor-derived exosomal miRNAs in the development and reprogramming of the tumor microenvironment.
We encourage authors to submit original research, systematic reviews, and review articles that address miRNA/lncRNA profiling, their role in breast cancer diagnosis and prognosis as biomarkers, and techniques using exosomal miRNAs/lncRNAs to prevent cancer proliferation as a therapeutic intervention, including but not limited to the following topics.
- Exosomal microRNAs/lncRNAs for breast cancer treatment
- Exosomal microRNAs/lncRNAs as biomarkers for breast cancer diagnosis and prognosis
- Targeted exosomes as microRNA/lncRNAs carriers
