Type 2 diabetes is a metabolic chronic disease defined by hyperglycemia. In pre-diabetic state, peripheral tissues show an incapacity to fully respond to insulin, known as insulin resistance. The rise in insulin secretion by pancreatic islets to counteract peripheral insulin resistance results, over time, in beta cell fatigue and apoptosis. One of the major metabolic defects that arises before the development of type 2 diabetes is muscle insulin resistance. Since muscle is the biggest glucose consumer in the postprandial period (in the presence of insulin), improving muscle insulin sensitivity helps in the management of hyperglycemia. A way to improve muscle glucose uptake and insulin sensitivity is exercise training. Interestingly, exercise training also has a positive effects of other metabolic disorders found with type 2 diabetes, such as improved insulin secretion, decreased hepatic glucose production and liver insulin sensitivity, and improves adipose tissue metabolism.
Exercise training is thus one of the non-pharmacological intervention recommended to patients living with type 2 diabetes, but also to individuals at risk to develop the disease. However, how exercise improves hyperglycemia is not completely understood. Furthermore, defining the types of exercise with the best result in the management of hyperglycemia is still under investigation.
The goal of this Research Topic is to provide a platform for original research and review articles that shed more light on how exercise training helps in the management of type 2 diabetes at the molecular, cellular and physiological levels.
We encourage interested scientists, clinicians, and exercise specialists to submit their contributions with a specific focus on:
- The comparison of different types of exercise intervention in the management of metabolic and endocrine defects seen with pre-diabetes and type 2 diabetes
- The molecular and metabolic pathways positively altered in tissues involved in diabetes (e.g. pancreatic beta cells, skeletal muscle, liver, adipose tissue) in response to exercise interventions in individuals with pre-diabetes and type 2 diabetes
- The improvement of crosstalk between tissues in response to exercise intervention in the context of pre-diabetes and type 2 diabetes
- Differential responses to exercise interventions between men and women (i.e. sexual dimorphism)
Type 2 diabetes is a metabolic chronic disease defined by hyperglycemia. In pre-diabetic state, peripheral tissues show an incapacity to fully respond to insulin, known as insulin resistance. The rise in insulin secretion by pancreatic islets to counteract peripheral insulin resistance results, over time, in beta cell fatigue and apoptosis. One of the major metabolic defects that arises before the development of type 2 diabetes is muscle insulin resistance. Since muscle is the biggest glucose consumer in the postprandial period (in the presence of insulin), improving muscle insulin sensitivity helps in the management of hyperglycemia. A way to improve muscle glucose uptake and insulin sensitivity is exercise training. Interestingly, exercise training also has a positive effects of other metabolic disorders found with type 2 diabetes, such as improved insulin secretion, decreased hepatic glucose production and liver insulin sensitivity, and improves adipose tissue metabolism.
Exercise training is thus one of the non-pharmacological intervention recommended to patients living with type 2 diabetes, but also to individuals at risk to develop the disease. However, how exercise improves hyperglycemia is not completely understood. Furthermore, defining the types of exercise with the best result in the management of hyperglycemia is still under investigation.
The goal of this Research Topic is to provide a platform for original research and review articles that shed more light on how exercise training helps in the management of type 2 diabetes at the molecular, cellular and physiological levels.
We encourage interested scientists, clinicians, and exercise specialists to submit their contributions with a specific focus on:
- The comparison of different types of exercise intervention in the management of metabolic and endocrine defects seen with pre-diabetes and type 2 diabetes
- The molecular and metabolic pathways positively altered in tissues involved in diabetes (e.g. pancreatic beta cells, skeletal muscle, liver, adipose tissue) in response to exercise interventions in individuals with pre-diabetes and type 2 diabetes
- The improvement of crosstalk between tissues in response to exercise intervention in the context of pre-diabetes and type 2 diabetes
- Differential responses to exercise interventions between men and women (i.e. sexual dimorphism)