Chronic Pain: What is the Mechanism?

Chronic pain is a complex and debilitating condition that demands in-depth scientific scrutiny. In this pursuit, this Research Topic will investigate the role of endogenous ligands in pain and inflammation. Transient receptor potential cation channels (TRPs) are the major pain receptors in the body. They are activated by heat, cold, pressure and a number of endogenous ligands, such as the endocannabinoids, leukotrienes and chemokines. TRPs and the sensory neurons they activate release inflammatory factors such as neurokinins that can induce inflammation even at distant sites. Bradykinin and prostaglandins have important roles in pain and inflammation as well. There is a complex interplay between these factors that is responsible for pain and chronic pain.

This Research Topic aims to explore endogenous ligands in pain, chronic pain and inflammation, including chemokines, leukotrienes, bradykinin, endocannabinoids and other compounds. Drug-induced changes in these endogenous ligands will be of particular interest. Chronic pain is a medically significant and complex condition, and understanding the role of these molecules can provide critical insights into potential therapeutic interventions. Through rigorous scientific inquiry, we aim to contribute to the scholarly understanding of pain mechanisms and advance the development of more effective pain management strategies

We welcome the following article types: Original Research, Reviews, and Opinion.

Keywords: Pain, Chronic Pain, Transient Receptor Potential Cation Channels, Chemokines, Bradykinin

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.