Research Topic

Renal Injury and the Brain

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About this Research Topic

Both neurological and renal diseases are worldwide public health problems that often have complex medical issues and might lead to detrimental consequences. These diseases are often associated with a decreased quality of life and increased mortality and morbidity rates. But what happens when these two are ...

Both neurological and renal diseases are worldwide public health problems that often have complex medical issues and might lead to detrimental consequences. These diseases are often associated with a decreased quality of life and increased mortality and morbidity rates. But what happens when these two are combined?

Decreased kidney function is associated with cognitive impairment and it has been reported that a decreased cognitive functioning appears to 60% of patients with chronic kidney disease. For example, it has been proved that patients with acute kidney injury have a different cerebral blood flow and other neurological alterations, mainly due to a vascular dysfunction. Whether these changes are due to alterations in inflammation, structural abnormalities, hypertension and/or other factors still remains unclear and causes much debate. Several studies, trying to identify cross-talk between the brain and the kidney, have been conducted, yet, there is a lot of ground left to cover.

Therefore, in this Research topic we would like to collect original papers or reviews to help expand our current knowledge base on the relationship between brain and renal injury, to understand the sequence of events that contribute to cognitive impairment and their associated mechanisms, as well as, to measure their extent and examine their possible relation with other diseases. We welcome authors to submit manuscripts that could provide a deeper understanding on the association between then and not only help to move the field of renal injury and cognition forward, but also to impact majorly clinical practice.


Keywords: chronic kidney disease, cognitive impairment, cognition, CKD, kidney function, neurological changes


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