Research Topic

The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease

About this Research Topic

IGFs and insulin are conserved throughout evolution to mediate the effects of nutrition on growth, metabolism and development. As such, IGF and insulin play fundamental roles in normal physiology and in disease states. They modulate diverse aspects of cell function such as proliferation, differentiation, survival and metabolism, in many different physiological systems in the body. Unlike insulin however the bioactivity of IGFs is regulated by a family of six high-affinity binding proteins (IGFBPs) that confer specificity to these pluripotential growth factors. In addition, evidence shows IGF-independent actions of certain of the IGFBPs can directly modulate insulin sensitivity.

This Research Topic will feature experts in the IGF field who will encompass the latest, ground-breaking information regarding key characteristics of the structural biology of the IGF/insulin family and signaling pathways they initiate and regulate, in addition to their roles in normal physiology and disease states such as and not limited to ageing, host microbe interactions, stem cell biology, cancer and metabolic disease. This Research Topic will highlight key discoveries that will indicate that several components of the IGF/insulin-IGFBP system could be explored for therapeutic potential.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

IGFs and insulin are conserved throughout evolution to mediate the effects of nutrition on growth, metabolism and development. As such, IGF and insulin play fundamental roles in normal physiology and in disease states. They modulate diverse aspects of cell function such as proliferation, differentiation, survival and metabolism, in many different physiological systems in the body. Unlike insulin however the bioactivity of IGFs is regulated by a family of six high-affinity binding proteins (IGFBPs) that confer specificity to these pluripotential growth factors. In addition, evidence shows IGF-independent actions of certain of the IGFBPs can directly modulate insulin sensitivity.

This Research Topic will feature experts in the IGF field who will encompass the latest, ground-breaking information regarding key characteristics of the structural biology of the IGF/insulin family and signaling pathways they initiate and regulate, in addition to their roles in normal physiology and disease states such as and not limited to ageing, host microbe interactions, stem cell biology, cancer and metabolic disease. This Research Topic will highlight key discoveries that will indicate that several components of the IGF/insulin-IGFBP system could be explored for therapeutic potential.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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