It is widely acknowledged that achieving and maintaining a healthier lifestyle can be enhanced through systematic, regular participation in exercise, physical activity, and/or sport. In parallel, evidence indicates for those who have lost their health (e.g., through diabetes, dementia, cardiovascular disease, ...
It is widely acknowledged that achieving and maintaining a healthier lifestyle can be enhanced through systematic, regular participation in exercise, physical activity, and/or sport. In parallel, evidence indicates for those who have lost their health (e.g., through diabetes, dementia, cardiovascular disease, osteoporosis, osteoarthritis, or sarcopenia) or have been injured, rehabilitative and restorative exercise may augment their return to more robust health. The basis for these positive effects is inextricably linked to the integrated and dynamic nature of our physiological systems (e.g., skeletal muscles, bones, cartilage, ligaments, tendons, neural and cardiovascular systems). Humans have evolved with exercise as one of the quintessential features for optimal function and well-being. Across the lifespan, however, from children to middle age to elderly there is heightened awareness that the negative effects of obesity and inactivity are becoming pandemic across cultures. Obesity is recognized as a chronic low-grade systemic inflammatory condition that predisposes to chronic conditions including metabolic syndrome. While obesity has clear pathophysiological links to cardiovascular conditions and type 2 diabetes, its effects can also extend to musculoskeletal (e.g., muscle, bone, tendon, and joints) complications and diseases that can exacerbate metabolic syndrome. Impaired muscle integrity (e.g., sarcopenia and intramuscular lipid accumulation) contribute to metabolic dysfunction.
The interconnectivity and multi-level interactions in physiological systems highlight the need for an integrative approach to reveal underlying mechanisms and effects of positive interventions (e.g., exercise, diet, rest/sleep, and psychology) on optimal health, mobility, and function across the lifespan.
This Research Topic focuses on collecting original basic and pre-clinical research articles, clinical studies, and review articles that address state-of-the-art advancements about optimizing integrative physiology across the lifespan.
Potential topics include but are not limited to:
• Children/Youth Physical Activity and Growth/Development
• Behavioral, Psychological, and Physical Activity Factors in Successful Aging
• Nutrition, Physical Activity, and Optimal Health
• Obesity, Metabolic Syndrome, and Musculoskeletal System
• Diet, Energy/Hormonal Balance, and Exercise — Limits to Ultimate Performance
• Sex Differences in Exercise Responses across the Lifespan
• Genetic and Epigenetic Exercise Adaptations for Optimal Mobility and Function
• Integrating the Microbiome, Diet, and Mobility
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.