About this Research Topic
Increasing evidence has pointed towards the implication of inflammation in schizophrenia, and patients with schizophrenia have increased pro-inflammatory markers and a higher prevalence of inflammatory diseases. In addition, genetic studies have pointed towards the role of the immune system in schizophrenia and RCTs have found antipsychotic effects of anti-inflammatory drugs. The causal relationship of these findings still remains less well understood.
This Research Topic will be a selection of Review and Original Research articles focusing on several important aspects of the potential schizophrenia-inflammation association. It will range from the genetic links, findings of inflammation and inflammatory diseases in schizophrenia, the gut-microbiome-brain axis, the role of autoimmune antibodies, whether specific infectious agents may cause schizophrenia, to the possibility of using anti-inflammatory drugs in schizophrenia and measuring neuroinflammation and microglial activity via brain scans. Furthermore, the potential causal relationships will be discussed in separate expert reviews.
Keywords: Schizophrenia, Inflammation, Psychoimmunology, Anti-Inflammatory Drugs
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