About this Research Topic
In the past decade, major progress has been made in understanding the architecture and functionalities of excitatory synapses. These advances, largely triggered by the advent of novel technologies (cryo-electron and super-resolution microscopy, optogenetics and optopharmacology, deep sequencing, single-cell genetics, etc…) have profound implications in our understanding of the normal and disease brain.
This Research Topic aims to capture recent progress and excitement across the breadth of synapse biology, with a focus on glutamatergic synapses of the mammalian brain and an emphasis on molecular, cellular, physiological and physiopathological mechanisms.
We aim to cover the following topics:
- Glutamate receptor structure, regulation and trafficking
- Synapse maturation and scaffolding
- Signaling mechanisms at excitatory synapses
- Experience-dependent modulation of synapses and circuits
- Synaptic plasticity and behavior
- Synaptic dysfunction in neuropsychiatric disorders.
Besides the journal Frontiers in Synaptic Neuroscience, we envision strong interest for sister Frontiers journals, including Frontiers in Molecular Neuroscience, Frontiers in Cellular Neuroscience and Frontiers in Behavioral Neuroscience.
Keywords: Synapse, Receptor, Neuron, Plasticity, Neurodevelopmental disorders
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.