Research Topic

The Golden Era: Gold Nanomaterials for Bioapplications

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Gold nanomaterials serve as critical bridges that connect the missing link between atomic structure and bulk metal. In this size regime, gold nanomaterials exhibit fascinating physical and chemical properties that truly stand out from many other nanostructures, making them outstanding candidates for ...

Gold nanomaterials serve as critical bridges that connect the missing link between atomic structure and bulk metal. In this size regime, gold nanomaterials exhibit fascinating physical and chemical properties that truly stand out from many other nanostructures, making them outstanding candidates for biological related applications. Over the past decades, significant effort and remarkable progress have been made to design and synthesize gold nanomaterials for different applications including bioimaging, biosensing, diagnosis, drug delivery and photothermal therapy. A “golden era” for bioapplications has started to emerge.

Despite the positives, however, many challenges still exist that impede the potential translation of gold nanomaterials for clinical usage. For instance, innovative surface chemistry modification and fundamental understanding on protein-nanoparticle interactions are greatly anticipated to enhance their efficiency for drug-graft, delivery and therapeutic purpose; While some breakthroughs on the in vivo clearance routes of gold nanomaterials have been made, approaches to optimize clearance profile, minimize nonspecific binding, and improve immune response are still highly desired. Taken together, the flourish of a “golden era” will be heavily relied on future works that overcome these critical limitations.

This Research Topic is dedicated to the most recent advances that tackle significant scientific challenges and improve our fundamental understanding related to gold nanomaterials and their bioapplications. Potential themes of contribution include, but not limited to
• Synthesis and characterization of gold nanomaterials for bioimaging and biosensing applications
• Functionalization and modification of gold nanomaterials for diagnostic, drug delivery and therapeutic applications.
• Fundamental understanding on bio-nano interfaces of gold nanomaterials.
• Systematic investigation on nanotoxicity, biodistribution and immunological properties of gold nanomaterials. Descriptive characterization studies and work solely reporting on toxicity however do not fall within the scope of the collection and all studies must bring a clear mechanistic understanding.
We cordially welcome the submission of original research articles, mini and full-length reviews, and perspectives that relate to this research topic.


Keywords: Gold Nanomaterials, Bioimaging, Biomedical Applications, Bio-nano Interface, Nanotoxicity


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