Research Topic

The Search for Biomarkers in Psychiatry

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The identification of biomarkers in psychiatry is becoming essential to facilitate diagnosis and select the most appropriated treatment for each patient. In contrast to other diseases, mental illnesses present the peculiarity to be classified by diagnostic categories with a broad and variable list of ...

The identification of biomarkers in psychiatry is becoming essential to facilitate diagnosis and select the most appropriated treatment for each patient. In contrast to other diseases, mental illnesses present the peculiarity to be classified by diagnostic categories with a broad and variable list of symptoms.

Therefore, patients diagnosed with the same psychiatric illness present a great heterogeneity in their clinical presentation. Furthermore, our knowledge about the molecular mechanisms underlying mental disorders, and consequently clinical pharmacological options, is still limited. In this respect, an extraordinary effort has been developed in the last years to identify biomarkers associated to different psychiatric conditions as potential tools for prevention, diagnosis and prognostic in mental illness.

In this Research Topic, we welcome original and review articles regarding new advances of peripheral and central biomarkers using a variety of methods (proteomics, transcriptomics, genetics, and imaging) in clinical conditions and postmortem samples in an attempt to identify alterations with specific traits of the disease or with the outcome of the pharmacological treatments. In summary, the identification and validation of biomarkers in psychiatry will help to more precisely classify specific features associated with mental diagnosis and facilitate the discovery of more effective treatments.


Keywords: genetics, neuroimage, brain, protein, biomarker


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