Endometriosis is a complex disorder that has been the source of many international publications and the two main symptoms associated with it are pain and infertility. However, its aetiology remains mysterious and it seems to have multiple causes. Moreover, endometriosis lesions are very heterogeneous in terms of their location (deep endometriosis, superficial, ovarian cyst), their extent (associated symptoms) and the evolution, and aggressiveness, of the symptoms and responses to treatments. In other words, endometriosis evolves in pushes, remains autonomous and is responsible for superficial and deep lesions.
In this Research Topic, we think that we must go much further and propose an amendment to the medical classification in order take into account the evolution of the lesions, and their deep molecular biology. Most importantly, this will allow us to acknowledge the reality that these lesions are not at the same stage: We have begun to demonstrate (10) an embryological origin, chromosomal instability, genomic and proteomic abnormalities (2, 3 and 4), and problems related to pharmacologic testing during a wild hormone therapy that does not take into account the phenotype of lesions. The peritoneal fluid is one of the factors of diffusion of the endometriosis in the rest of the organism (9, 5): ovaries, deep forms under and peritoneal. Finally, in 9 cases we have demonstrated where there is a possible embryologic origin. Overall, the aim of this Research Topic is to propose non-invasive diagnoses, explanations for pathogeny, non-invasive surgical treatments and to decrease infertility time.
Endometriosis is a complex disorder that has been the source of many international publications and the two main symptoms associated with it are pain and infertility. However, its aetiology remains mysterious and it seems to have multiple causes. Moreover, endometriosis lesions are very heterogeneous in terms of their location (deep endometriosis, superficial, ovarian cyst), their extent (associated symptoms) and the evolution, and aggressiveness, of the symptoms and responses to treatments. In other words, endometriosis evolves in pushes, remains autonomous and is responsible for superficial and deep lesions.
In this Research Topic, we think that we must go much further and propose an amendment to the medical classification in order take into account the evolution of the lesions, and their deep molecular biology. Most importantly, this will allow us to acknowledge the reality that these lesions are not at the same stage: We have begun to demonstrate (10) an embryological origin, chromosomal instability, genomic and proteomic abnormalities (2, 3 and 4), and problems related to pharmacologic testing during a wild hormone therapy that does not take into account the phenotype of lesions. The peritoneal fluid is one of the factors of diffusion of the endometriosis in the rest of the organism (9, 5): ovaries, deep forms under and peritoneal. Finally, in 9 cases we have demonstrated where there is a possible embryologic origin. Overall, the aim of this Research Topic is to propose non-invasive diagnoses, explanations for pathogeny, non-invasive surgical treatments and to decrease infertility time.