Research Topic

The Tumor Necrosis Factor Superfamily: an Increasing Role in Breast Cancer

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About this Research Topic

The Tumor Necrosis Factor (TNF) superfamily (TNFSF) encompasses a wide range of TNFSF ligands that mediate their biological effects through binding to their cognate TNF receptor superfamily (TNFRSF) members. These molecules have physiological roles in both innate and adaptive immunity and have been implicated ...

The Tumor Necrosis Factor (TNF) superfamily (TNFSF) encompasses a wide range of TNFSF ligands that mediate their biological effects through binding to their cognate TNF receptor superfamily (TNFRSF) members. These molecules have physiological roles in both innate and adaptive immunity and have been implicated in diverse pathological conditions such as autoimmune diseases, developmental abnormalities, and cancer. TNFSF members serve as activators of signaling pathways that mediate inflammation, cell survival, and apoptosis. The TNF superfamily is also important in tumorigenesis, as both pro- and anti-tumor effects have been demonstrated. There has been considerable investigation into the role of the most well-recognized member of this family, TNF-alpha, in the progression of breast cancer. However, many other TNF family members are now being shown to have a role in breast cancer biology.

The aim of this Research Topic is to increase mechanistic and functional understanding of the role of TNF and TNFR superfamilies in breast cancer and provide insight into the potential for targeting this pathway as part of treatment strategies.

This collection will focus on the expanding role and potential for targeting TNFSF and TNFRSF members in breast cancer. We welcome articles including Original Research and Review articles that focus on but are not limited to:

1) TNFSF members and TNFRSF signaling pathways associated with breast cancer.
2) Novel contributions of TNFSF and TNFRSF members to breast cancer biology, as well as advancements or summaries of subsets of these superfamily members that have already been linked to breast cancer, such as TNF-alpha.
3) Linking expression of TNFSF and TNFRSF members with the development and progression of breast cancer as well as association with patient outcomes and prognosis.
4) In vitro and in vivo studies that modulate expression or activity of TNFSF and TNFRSF members to determine the impact on breast cancer development and progression will also be considered.


Keywords: TNF superfamily, TNFR superfamily, breast cancer


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