Research Topic

Current Perspectives of Antimicrobial Resistance in Campylobacteraceae and Helicobacteraceae

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About this Research Topic

Campylobacteraceae and Helicobacteraceae are two large and diverse families within the Epsilon subdivision of Proteobacteria that share morphologic and ecologic characteristics. To these families belong to the genera Campylobacter, Helicobacter and Arcobacter, which include major and emerging pathogens that have been mainly associated with gastroenteric diseases in humans and animals.
Antibiotic resistance poses a major global concern for public health, as it is a growing threat to the effective treatment of an increasing range of infections caused by bacteria. It has been hypothesized that, especially for zoonotic bacteria, like the ones cited above, the resistance may derive from the interaction between humans and animals, as well as with the environment. The extensive use of antibiotics in clinical and veterinary settings may be a determinant for this resistance. However, considering the current national and international regulations of antibiotic use, the role of other possible determinants for this resistance, such as the presence of antibiotics or metals in the environment, or horizontal gene transfer through the animal-human-environment interface should also be assessed.
Although the knowledge on the mechanisms underlying the resistance to antibiotics in Campylobacteraceae and Helicobacteraceae has evolved, it is crucial to combine traditional and modern genetic and phenotypic approaches to assess the antimicrobial resistance pathways and their associated genetic mechanisms of transmission and persistence, as well as the forces that lead to their evolution. In this line, the development of culture-based or culture-independent methods for rapid antibiotic resistance detection will help to improve the surveillance of the trends for resistance. Moreover, innovative ways to surmount these resistances, such as new synthetic molecules, natural products, synergistic interactions between compounds, amongst others, are essential to overcome the challenges associated with animal and human health, but also food safety hazards. Therefore, this Research Topic is focused on studies regarding antibiotic resistance of Campylobacteraceae and Helicobacteraceae, its driving forces, spreading and novel approaches to detect, control and overcome this resistance.

Manuscripts (Original Research Articles, Reviews, Mini-reviews, Perspectives, and Brief research reports) that address one or more of the following themes are invited:
-Antibiotic resistance surveillance
-Evolutionary courses leading towards antibiotic resistance
-Drivers and sources of antimicrobial resistance
-Genomic and transcriptomic studies of antibiotic resistance
-Spread of antimicrobial resistance genes among reservoirs and in the environment as well as its risk factors associated
-Innovative approaches to overcome antibiotic resistance


Keywords: Campylobacteraceae, Helicobacteraceae, Antibiotic resistance, Resistome, Alternative therapies.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Campylobacteraceae and Helicobacteraceae are two large and diverse families within the Epsilon subdivision of Proteobacteria that share morphologic and ecologic characteristics. To these families belong to the genera Campylobacter, Helicobacter and Arcobacter, which include major and emerging pathogens that have been mainly associated with gastroenteric diseases in humans and animals.
Antibiotic resistance poses a major global concern for public health, as it is a growing threat to the effective treatment of an increasing range of infections caused by bacteria. It has been hypothesized that, especially for zoonotic bacteria, like the ones cited above, the resistance may derive from the interaction between humans and animals, as well as with the environment. The extensive use of antibiotics in clinical and veterinary settings may be a determinant for this resistance. However, considering the current national and international regulations of antibiotic use, the role of other possible determinants for this resistance, such as the presence of antibiotics or metals in the environment, or horizontal gene transfer through the animal-human-environment interface should also be assessed.
Although the knowledge on the mechanisms underlying the resistance to antibiotics in Campylobacteraceae and Helicobacteraceae has evolved, it is crucial to combine traditional and modern genetic and phenotypic approaches to assess the antimicrobial resistance pathways and their associated genetic mechanisms of transmission and persistence, as well as the forces that lead to their evolution. In this line, the development of culture-based or culture-independent methods for rapid antibiotic resistance detection will help to improve the surveillance of the trends for resistance. Moreover, innovative ways to surmount these resistances, such as new synthetic molecules, natural products, synergistic interactions between compounds, amongst others, are essential to overcome the challenges associated with animal and human health, but also food safety hazards. Therefore, this Research Topic is focused on studies regarding antibiotic resistance of Campylobacteraceae and Helicobacteraceae, its driving forces, spreading and novel approaches to detect, control and overcome this resistance.

Manuscripts (Original Research Articles, Reviews, Mini-reviews, Perspectives, and Brief research reports) that address one or more of the following themes are invited:
-Antibiotic resistance surveillance
-Evolutionary courses leading towards antibiotic resistance
-Drivers and sources of antimicrobial resistance
-Genomic and transcriptomic studies of antibiotic resistance
-Spread of antimicrobial resistance genes among reservoirs and in the environment as well as its risk factors associated
-Innovative approaches to overcome antibiotic resistance


Keywords: Campylobacteraceae, Helicobacteraceae, Antibiotic resistance, Resistome, Alternative therapies.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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