Research Topic

Novel Insights into The Immunology of Pulmonary Granulomatous Diseases

  • Submission closed.

About this Research Topic

Pulmonary granulomas appear in a heterogeneous group of diseases that present with variable clinical characteristics often challenging to diagnose. Granulomas themselves are non-specific histopathological entities that may be present in either infectious or non-infectious diseases.

Sarcoidosis is a ...

Pulmonary granulomas appear in a heterogeneous group of diseases that present with variable clinical characteristics often challenging to diagnose. Granulomas themselves are non-specific histopathological entities that may be present in either infectious or non-infectious diseases.

Sarcoidosis is a multi-organ granulomatous disease considered to occur from exposure to poorly soluble environmental antigen(s) which provoke host inflammatory and/or adaptive immune responses. Currently, the identity of such an antigen has not been confirmed in sarcoidosis. Diagnosis is usually determined by clinical history, biopsy findings of non-caseating granulomas with adjacent inflammatory cell infiltrates, and negative studies for active infection.

The aim of this Research Topic is to present current understanding of the causation and immune cellular mechanisms associated with granulomatous diseases, with a focus on sarcoidosis, a granulomatous disease of obscure etiology. We also seek to highlight new directions for investigative and diagnostic approaches targeting the immune system to treat sarcoidosis and other granulomatous conditions.

We welcome the submission of Reviews, Original Research, and articles relating to pulmonary granulomatous diseases and focusing on the following immunological aspects:

• Environmental risk factors;
• Epidemiology of sarcoidosis;
• Mechanisms involving alveolar macrophage activation;
• Immunological markers to characterize the immunopathogenesis of sarcoidosis;
• Experimental models studying the immune response in pulmonary granulomatous diseases;
• Characterization of Th1 pathways in beryllium lung disease/sarcoidosis;
• Th17-mediated pathophysiology of sarcoidosis/ pulmonary granulomatous diseases;
• Carbon nanotubes and granuloma formation;
• Current approaches targeting the immune system for treatment of sarcoidosis.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..