Research Topic

Host Biomarkers as Specific or General Indicators for Infections

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About this Research Topic

As the global population continues to grow, so too will vulnerable populations, such as the elderly and those with immunodeficiencies, who have increased susceptibility to infectious agents. Additionally, zoonoses are spreading all over the world due to the environmental changes, that can emerge in regions ...

As the global population continues to grow, so too will vulnerable populations, such as the elderly and those with immunodeficiencies, who have increased susceptibility to infectious agents. Additionally, zoonoses are spreading all over the world due to the environmental changes, that can emerge in regions impacted by deforestation or with limited resources.

Therefore, identifying emerging pathogens and new biomarkers by understanding host-responses and their underlying mechanisms is crucial as well as developing new tools for performing rapid diagnostics of infectious diseases and detecting antimicrobial resistance.

The host immune response and damaged tissues can be used as a biomarker source. More specifically, different soluble mediators can serve as new biomarkers such as: Danger Associated Molecules (DAMs) released by damaged or infected cells, or Th1 and Th2 cytokines released by immune cells and chemokines such as IP-10. Matrix proteins and matricellular proteins changes during infections may also be used as biomarkers for innovating diagnostics. New diagnostic methods aim at using exosomes containing these biomarkers or immune micro-RNAs.

This Research Topic aims at discussing novel diagnostic methods for infectious diseases using immune-mediate biomarkers. We welcome submissions of Original research, Clinical trial and Method articles focusing on novel biomarkers for the development of diagnostic methods for infectious diseases, including:
1. Cytokines as biomarkers
2. Chemokines as biomarkers
3. Matrix proteins as biomarkers


Keywords: Biomarker, Infectious diseases, Diagnostic, Host


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