Research Topic

Posttranslational Modification of Intercellular Messenger Systems

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While it is estimated that the human genome comprises ~27,000 genes, the total number of proteins in the human proteome is estimated at over 1 million. In addition to changes at the transcriptional and mRNA levels, “posttranslational modification of proteins” increases the functional diversity of the ...

While it is estimated that the human genome comprises ~27,000 genes, the total number of proteins in the human proteome is estimated at over 1 million. In addition to changes at the transcriptional and mRNA levels, “posttranslational modification of proteins” increases the functional diversity of the proteome. Now, it is increasingly recognized that posttranslational modifications of proteins provide important roles in a wide range of “intercellular signaling pathways”, such as endocrine systems. For example, n-octanoyl modification at Ser(3) is essential for ghrelin-induced bioactivities. Moreover, gaseous messengers, such as nitric oxide and hydrogen sulfide, are highly active and affect the functions of target proteins by S-nitrosylation and S-sulfhydration, respectively.
This Research Topic aims to assemble a series of review articles and original research papers on structural analysis or functional significance of posttranslational modification of/by intercellular messengers, including hormonal messengers and gaseous messengers, in animals and plants. The contributing papers may illustrate variety and importance of biological events regulated by posttranslational modification of functional molecules, and become major references for those working in the field of physiology and cell biology.


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