About this Research Topic
The high prevalence of non-fermenting Gram negative bacteria in clinical settings has been reported from different areas all over the world. These bacteria, especially Acinetobacter baumannii and Pseudomonas aeruginosa, cause a variety of infections types including bloodstream infection, respiratory infection, urinary infection, wound infection, and so on. Due to the presence of complicated antibiotic resistance mechanisms, these bacterial isolates always exhibit multidrug resistance (MDR), and antimicrobial treatment for their infections is greatly hampered. To control the related infections, we need to carry out more investigations on the molecular epidemiology, bacterial virulence, resistance mechanism and antimicrobial thermotherapy strategies for these bacteria.
In this Research Topic, we would like to focus on the following questions:
1. What are the key environmental and bacterial factors in non-fermenting Gram negative bacteria for survival, transmission and infection in clinical settings? Epidemiological techniques, genetic and genomic investigations and animal models may be used to characterize the details.
2. What are the key mechanisms for the evolution of multidrug resistance in these bacteria? The genomic basis of type MDR strains should be investigated and potential interactions of these factors should be characterized.
3. How to treat the infection cause by MDR non-fermenting Gram negative bacteria? Detail clinical management and antimicrobial strategies should be recorded to evaluate the efficacy.
We welcome full-length articles and reviews concerning the following themes:
• Epidemiology of MDR non-fermenting Gram negative bacteria in different clinical scenarios.
• Resistance mechanism for non-fermenting Gram negative bacteria with clear genetic evidence.
• Treatment of infection caused by MDR non-fermenting Gram negative bacteria.
Keywords: MDR, non-fermenting Gram negative bacteria, antimicrobial chemotherapy, resistance mechanism, epidemiology
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