About this Research Topic
Two-dimensional (2D) cell culturing has been the predominant method used to culture cells and although it plays a vital role in research, it is limited by its inability to accurately represent tissue cells in vitro. Three-dimensional (3D) cell culturing techniques are very unique in the way that they allow different types of cells to be replicated in vivo while providing an accurate representation of cell growth in vitro. Cells grown in a 3D model have proven to be more physiologically relevant and showed improvements in numerous studies of biological mechanisms. Moreover, 3D cell cultures offer the exciting potential for the development of novel medicines and increased productivity, with the most common applications being disease modelling, oncology and drug screening.
In this Research Topic, we invite you to contribute Original Research articles, Reviews, or Perspective articles on all aspects related to the theme of “Going the Distance: Enabling 3D Cell Culture Systems for Biomedical Research and Drug Treatment”. We hope to highlight the current methodologies, applications, and challenges with practical insight on ways to improve 3D techniques, and advance 3D culture system for biomedical research and therapy.
Suggested topics for your consideration:
1. New techniques of 3D cell culture systems
2. Advances and progression of 3D cell culture systems
3. Organoids, spheroids, and 3D cell culture
4. 3D cell culture systems and their applications in stem cell research
5. 3D cell culture systems and their applications in cancer research
6. 3D cell culture systems and their applications in drug discovery
7. Development of novel 3D cell culture disease models
8. 3D cell culture to model cellular microenvironment
9. 3D cultures to study drug efficacy, toxicity, and metabolism
10. Design and analysis of preclinical data using 3D cultures
11. Preclinical or clinical application of tissue engineered medicinal products
12. Increasing translation success with 3D cell culture systems
Keywords: 3D Cell Culture, Stem Cell, Cancer Research, Drug Development, Organoid or Spheroid Models
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.