Unraveling the fine details of ribosome synthesis and structure, and working out their role in regulating the protein synthesis process, is an emerging topic that is gaining increasing importance in understanding how protein homeostasis is qualitatively and quantitatively regulated in the cells. While a wealth of information is available on the ribosomes of bacteria and eukarya, much less is known about the synthesis and structure of archaeal ribosomes, and about the details of the translation process in the third domain of life. Furthermore, many important results are scattered around in the literature and are not comprehensively summarized to investigators working in the field.
The main purpose of this Research Topic is to provide a comprehensive outlook of the available information on archaeal ribosomes biogenesis, structure and function. The articles will present what is known on a number of specific subtopics, making comparisons (when possible) with the other domains of life, and will indicate emerging directions for future research.
Research and review articles addressing the following topics will be considered in priority:
• Ribosome structure across domains: similarities and differences.
• Ribosome function and regulation.
• Ribosomal RNAs: synthesis, processing and modification in archaea. Comparison with the other domains of life and identification of conserved features.
• Small RNAs and enzymes involved in rRNA processing: conservation and divergence.
• Proteins and cofactors participating in ribosome biogenesis in the three domains of life. Conserved and divergent features.
• Ribosome assembly.
• Translation in archaea. initiation, elongation, termination and ribosome recycling.
• Ribosome quality control (broadly speaking).
• Ribosome evolution.
• Challenges and emerging topics related to archaeal ribosomes research.
Unraveling the fine details of ribosome synthesis and structure, and working out their role in regulating the protein synthesis process, is an emerging topic that is gaining increasing importance in understanding how protein homeostasis is qualitatively and quantitatively regulated in the cells. While a wealth of information is available on the ribosomes of bacteria and eukarya, much less is known about the synthesis and structure of archaeal ribosomes, and about the details of the translation process in the third domain of life. Furthermore, many important results are scattered around in the literature and are not comprehensively summarized to investigators working in the field.
The main purpose of this Research Topic is to provide a comprehensive outlook of the available information on archaeal ribosomes biogenesis, structure and function. The articles will present what is known on a number of specific subtopics, making comparisons (when possible) with the other domains of life, and will indicate emerging directions for future research.
Research and review articles addressing the following topics will be considered in priority:
• Ribosome structure across domains: similarities and differences.
• Ribosome function and regulation.
• Ribosomal RNAs: synthesis, processing and modification in archaea. Comparison with the other domains of life and identification of conserved features.
• Small RNAs and enzymes involved in rRNA processing: conservation and divergence.
• Proteins and cofactors participating in ribosome biogenesis in the three domains of life. Conserved and divergent features.
• Ribosome assembly.
• Translation in archaea. initiation, elongation, termination and ribosome recycling.
• Ribosome quality control (broadly speaking).
• Ribosome evolution.
• Challenges and emerging topics related to archaeal ribosomes research.
