Research Topic

Skeletal Muscle Immunometabolism

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About this Research Topic

All tissues contain resident immune cells and additional immune cells can invade tissues in response to attractants released by the tissue itself. Immune populations are very plastic and can change their phenotype to adapt to the local environment, making each inflammatory response specific and precisely ...

All tissues contain resident immune cells and additional immune cells can invade tissues in response to attractants released by the tissue itself. Immune populations are very plastic and can change their phenotype to adapt to the local environment, making each inflammatory response specific and precisely adapted to its associated pathophysiological state. Inflammation of skeletal muscle is elevated after exercise, required for muscle growth and repair, increased in sarcopenia and a hallmark of myopathies. Inflammatory immune cells are also recruited to skeletal muscle during obesity and type 2 diabetes and myotubes in vitro can develop inflammatory responses under metabolic stress.

The fact that so many conditions are associated with skeletal muscle inflammatory responses, and sometimes lead to opposite effects on metabolic health highlights the complex and ambivalent role of skeletal muscle inflammation in controlling whole-body homeostasis.

Still, skeletal muscle inflammatory signatures to various contexts is poorly characterized, so this Research Topic will focus on studies that investigate and discuss:
- The role and type of inflammatory response occurring in skeletal muscle with different modes of exercise or sedentary behavior.
- The importance of the immune system for skeletal muscle development and repair.
- The link between skeletal muscle inflammation and whole-body metabolic regulations such as insulin sensitivity.
- Skeletal muscle inflammation during cachexia.
- The involvement of muscle inflammation in muscle frailty associated with ageing.


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