Research Topic

Potential Neurotoxic Effects of Perioperative Factors

About this Research Topic

With an increase in the geriatric population, it is predicted that cognitive impairment will be one of the most demanding healthcare problems for both patients and their health providers, consuming a growing fraction of healthcare resources. Postoperative neurocognitive disorder (PND) includes postoperative ...

With an increase in the geriatric population, it is predicted that cognitive impairment will be one of the most demanding healthcare problems for both patients and their health providers, consuming a growing fraction of healthcare resources. Postoperative neurocognitive disorder (PND) includes postoperative delirium and postoperative cognitive dysfunction (POCD), the most common postoperative complications in geriatric patients after anesthesia and surgery, which are important research areas in the field of geriatrics, neuroscience, anesthesia, and surgery.

Postoperative delirium and POCD are associated with a substantially higher risk for Alzheimer’s disease (AD) dementia, morbidity, mortality, and cost of care. However, the pathogenesis of postoperative delirium and POCD are still mostly unknown, which impede further studies in this field. Therefore, it is essential to study whether any peri-operative factors can induce damages of the central nervous system (CNS), leading to behavioral changes associated with postoperative delirium and POCD. Specifically, these factors include anesthesia, surgery, pain, sleep deprivation, and others. Currently, the potential neuropathogenesis of postoperative delirium and POCD may consist of apoptosis, mitochondrial dysfunction, neuroinflammation, Tau protein metabolism, beta-amyloid protein metabolism, and others. Yet, more studies are still needed to reveal the neuropathogenesis of postoperative delirium and POCD. Moreover, there have been no effective interventions of postoperative delirium and POCD. Thus, more studies to identify the targeted interventions of postoperative delirium and POCD are also needed.

Finally, in addition to postoperative delirium and POCD, there are reports of postoperative stroke and other postoperative brain damages. Therefore, it is important to study whether the peri-operative factors (e.g., anesthesia, surgery, pain, and sleep deprivation) are also associated with stroke or other brain damages.

Collectively, this Research Topic aims to welcome pre-clinical and clinical studies of postoperative delirium, POCD, postoperative stroke, and other postoperative brain damages, focusing on the studies of the role of peri-operative factors anesthesia, surgery, pain, and sleep deprivation in these disorders and including both mechanistic investigation and targeted intervention research for these disorders.

Topic Editor Zhongcong Xie is a consultant for Shanghai Jiaotong University, Tongji University, Baxter, Novartis and Hengrui pharmaceutical companies. The rest of Topic Editors declare no competing interests with regards to the Research Topic.


Keywords: Anesthesia, Surgery, Pain, Sleep, Brain, Postoperative neurocognitive disorder, Stroke and neurotoxicity


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Submission Deadlines

31 August 2020 Manuscript

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Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 August 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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