About this Research Topic
- Identification of signaling pathways and mechanisms that operate globally or locally to induce specific pre-synaptic adaptations.
- The nature of pre-synaptic ion channels relevant to this form of plasticity and their synapse-specific modulation and trafficking.
- Development and utilization of new tools or methods to study homeostatic plasticity in axons and pre-synaptic terminals
- Novel mechanisms of homeostatic adaptations in pre-synaptic neurons.
- Postsynaptic sensors of activity and retrograde synaptic signaling systems.
- A comprehensive analysis of the kinds of pre-synaptic adaptations in diverse neural circuits and cell types.
- Identification of physiological or developmental conditions that promote pre-synaptic homeostatic adaptations.
- How activity-dependent (Hebbian) and homeostatic synaptic changes are integrated to both permit sufficient flexibility and maintain stable activity.
- Relevance of pre-synaptic homeostatic plasticity to the etiology of neuropsychiatric disorders.
- Computational modeling of pre-synaptic homeostatic plasticity and network stability
- Mechanisms of intrinsic excitability in pre-synaptic neurons
To this end, we seek original articles, hypotheses and reviews that address these and other outstanding questions pertaining to this form of plasticity in a variety of model systems.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.