Research Topic

Novelties in the therapeutic approaches for chronic heart failure: cardiovascular targets and beyond

About this Research Topic

Despite the progress in the treatment of heart failure, it is a syndrome that is still characterized by high morbidity and mortality, a high socio-economic impact and whose management is particularly complex. Heart failure therapy can be extremely different in patients with reduced or preserved ejection fraction, in patients with acute decompensated or chronic heart failure, in patients with arrhythmias or in those with comorbidities. As a consequence, the emerging therapeutic options range from anti-modeling strategies, to electrical therapy, to management of congestion management, to the novel approaches for patients with preserved ejection fraction and comorbidities. The purpose of this special issue is to explore the most innovative therapeutic approaches for chronic heart failure, covering all its complexity.

This Special Issue welcomes original research and review articles about the therapeutic approaches for heart failure under development or under initial clinical evaluation. We encourage to submit both papers focused on cardiovascular drugs or electrical therapy and on treatment of those comorbidities favoring heart failure worsening.

Submissions are encouraged that discuss new cardiovascular drugs able to revert cardiac remodeling as well as increase inotropism. Articles focused on the congestion, from its monitoring to its management, until diuretic resistance, are also welcome. We encourage the submission of articles about electrical therapy of heart failure. In particular, the novelties in resynchronization therapy and the role of atrial fibrillation and ventricular malignant arrhythmias transcatheter ablation should be explored. Heart transplantation, stem cell therapy, cardiac assistance, unloading approaches for reverse remodeling, tissue engineering could be also topics of the articles. The novel strategies for the treatment of patients with preserved or mild reduced ejection fraction merit a separate and dedicate discussion. In particular, articles about emerging therapeutic strategies of infiltrative cardiomyopathies, such as amyloidosis, are welcome.
Moreover, we strongly encourage the submission of articles which delve more deeply into the treatment of comorbidities related to heart failure. These articles should discuss the new opportunities coming from SGLT2 inhibitors, from the treatment of endocrine diseases, such as growth hormone deficiency or thyroid deficiency, from the management of cardiorenal syndrome and hyperkalemia. Finally, papers focused on personalized therapeutic strategies based on patients’ monitoring are welcome.

The potential themes include, but are not limited, to the following:
1. Cardiovascular drugs
- Antiremodelling strategies
- New inotropes
- Management of congestion and diuretic resistance

2. Electrical therapy
- Resyncrhonization therapy
- Transcatheter ablation of atrial fibrillation and of malignant ventricular arrhythmias;

3. Heart transplantation, stem cell therapy, cardiac assistance, unloading approaches for reverse remodeling, tissue engineering

4. Heart failure with mild reduced or preserved ejection fraction
- New drugs
- therapeutic approaches of infiltrative cardiomyopathies

5. Other therapeutic approaches
- SGLT2 inhibitors
- Endocrine diseases
- Cardiorenal syndrome
- Management of hyperkalemia and renin-angiotensin-aldosterone inhibition

6. Remote monitoring and personalized therapeutic approaches


Keywords: Heart Failure, Therapy, Comorbidities, Prognosis, arrhythmias


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Despite the progress in the treatment of heart failure, it is a syndrome that is still characterized by high morbidity and mortality, a high socio-economic impact and whose management is particularly complex. Heart failure therapy can be extremely different in patients with reduced or preserved ejection fraction, in patients with acute decompensated or chronic heart failure, in patients with arrhythmias or in those with comorbidities. As a consequence, the emerging therapeutic options range from anti-modeling strategies, to electrical therapy, to management of congestion management, to the novel approaches for patients with preserved ejection fraction and comorbidities. The purpose of this special issue is to explore the most innovative therapeutic approaches for chronic heart failure, covering all its complexity.

This Special Issue welcomes original research and review articles about the therapeutic approaches for heart failure under development or under initial clinical evaluation. We encourage to submit both papers focused on cardiovascular drugs or electrical therapy and on treatment of those comorbidities favoring heart failure worsening.

Submissions are encouraged that discuss new cardiovascular drugs able to revert cardiac remodeling as well as increase inotropism. Articles focused on the congestion, from its monitoring to its management, until diuretic resistance, are also welcome. We encourage the submission of articles about electrical therapy of heart failure. In particular, the novelties in resynchronization therapy and the role of atrial fibrillation and ventricular malignant arrhythmias transcatheter ablation should be explored. Heart transplantation, stem cell therapy, cardiac assistance, unloading approaches for reverse remodeling, tissue engineering could be also topics of the articles. The novel strategies for the treatment of patients with preserved or mild reduced ejection fraction merit a separate and dedicate discussion. In particular, articles about emerging therapeutic strategies of infiltrative cardiomyopathies, such as amyloidosis, are welcome.
Moreover, we strongly encourage the submission of articles which delve more deeply into the treatment of comorbidities related to heart failure. These articles should discuss the new opportunities coming from SGLT2 inhibitors, from the treatment of endocrine diseases, such as growth hormone deficiency or thyroid deficiency, from the management of cardiorenal syndrome and hyperkalemia. Finally, papers focused on personalized therapeutic strategies based on patients’ monitoring are welcome.

The potential themes include, but are not limited, to the following:
1. Cardiovascular drugs
- Antiremodelling strategies
- New inotropes
- Management of congestion and diuretic resistance

2. Electrical therapy
- Resyncrhonization therapy
- Transcatheter ablation of atrial fibrillation and of malignant ventricular arrhythmias;

3. Heart transplantation, stem cell therapy, cardiac assistance, unloading approaches for reverse remodeling, tissue engineering

4. Heart failure with mild reduced or preserved ejection fraction
- New drugs
- therapeutic approaches of infiltrative cardiomyopathies

5. Other therapeutic approaches
- SGLT2 inhibitors
- Endocrine diseases
- Cardiorenal syndrome
- Management of hyperkalemia and renin-angiotensin-aldosterone inhibition

6. Remote monitoring and personalized therapeutic approaches


Keywords: Heart Failure, Therapy, Comorbidities, Prognosis, arrhythmias


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 June 2020 Abstract
30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 June 2020 Abstract
30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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