About this Research Topic
Non-coding DNA sequences are major components of an organism's genome. Genome-wide association studies (GWASs) have produced numerous genetic variants that are associated with phenotypes from different species and the majority of these associations are suggested to be mediated by non-coding regulatory codes. As large-scale genomic sequencing together with constantly evolving biotechnology revolutionize the functional genomics field, we still face great challenges to accurately predict, interpret and evaluate the biological functions of non-coding regulatory variants in the gene regulation.
This Research Topic aims to seek recent advances in understanding the regulatory potentials of non-coding genetic/somatic variants (e.g. affecting transcription, splicing or epigenetic activities) in various organisms using either computational or experimental methods. Novel approaches, tools and results for accurate regulatory variant prediction and classification, non-coding variant annotation, deleterious prioritization, functional assays for regulatory mechanism are recommended.
Contributions are welcome in several areas:
· Novel computational methods to annotate, predict, and prioritize the function, deleterious effects or
parthenogenesis of non-coding regulatory variants;
· New/updated databases or web servers for interpreting the association between non-coding regulatory
variants and complex traits in various species;
· Quantitative trait locus (QTL) studies on molecular phenotype in gene regulation;
· Investigations into functional validation and regulatory mechanisms for trait-associated non-coding variants;
· Reviews or perspective articles regarding the above mentioned subtopics.
Keywords: Non-coding variants, Regulatory variants, Variant annotation, Function prediction, Function validation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.