About this Research Topic
The encapsulation/complexation of drugs using biodegradable delivery systems, made up of phospholipids, polymers, polysaccharides, proteins, etc., demonstrated to be a suitable approach to modulate the biopharmaceutical properties of many active compounds. One of the most important advancements provided by the development of drug carries is the opportunity to bypass the biological barriers, promoting the cell uptake and the specific tissue localization of the entrapped bioactives and, consequently, increasing their therapeutic efficacy. In fact, even though the hydrophilic derivatives are easy to be administered, they are characterized by a broad body distribution; on the other hand, lipophilic drugs need the use of organic solvent or surfactants to be solubilized in polar media, inducing the appearance of significant side effects.
The aim of this Research Topic is to describe the advancements concerning the development of innovative biocompatible formulations able to favour the cell uptake of drugs characterized by different physico-chemical properties and their tissue localization, describing the most important involved mechanisms and the peculiar techniques used to evaluate these phenomena by means of in vitro and in vivo tests.
All researchers working in the field are cordially invited to contribute. Original Research papers, brief Communication Reports, as well as Review articles, are welcome.
Keywords: Self-assembling biosystems, phospholipids, biopolymers, (poly)saccharides, colloidal structures, microparticulates, drug delivery, intracellular/subcellular localization
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