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Experimental Pharmacology and Drug Discovery publishes research on mechanisms of drug action at the molecular, cellular and organism level by analyzing the interaction with receptors and/or other specific biological targets, including enzymes, ion channels, transporters, and transcription factors.
Specific requirements are detailed for the conception and review of manuscripts submitted to this specialty section of Frontiers in Pharmacology at the below link.
Experimental Pharmacology and Drug Discovery aims to publish significant basic research findings in pharmacology that shed light on mechanisms of drug action by analyzing the interaction with receptors and/or other specific biological targets, including enzymes, ion channels, transporters, transcription factors, etc... The study of drug-biomolecule interaction includes analysis of binding, transduction mechanisms, physiological responses, and pharmacokinetics at the molecular, cellular, and organism level. This section also welcomes papers on all aspects of modern drug discovery with respect to “small molecules” and biopharmaceuticals, such as target identification (high-throughput) screening and other lead-finding techniques, medicinal chemistry (lead-optimization case studies, drug synthesis, molecular modeling, parallel synthesis, and library design), pharmacokinetics, metabolism, pharmacology and toxicology of investigatory drugs, and results from clinical studies. While Experimental Pharmacology and Drug Discovery is primarily centered on pharmacological research of new agents, novel pharmacodynamic and pharmacokinetic mechanisms that may explain/predict clinical effects of drugs already in use and/or provide potential targets for drug development may occasionally also be welcome. Our ultimate goal is to encourage publication of pharmacological studies that implement drug discovery and the understanding of drug mechanisms of action.
Guidelines for the conception/peer-review of submissions
Studies carried out with crude extracts/multiherbal preparations will not be considered for review. In contrast, studies which utilize highly purified, chemically characterized compounds meet the minimum criteria for investigation of pharmacological effect.
Where extracts are claimed to meet such minimum criteria, chemical structure and purity must be precisely described by appropriate analytical methods (e.g. chromatography and/or mass spectrometry).
Original research based solely on in silico techniques will not be considered for review.
Indexed in: PubMed, PubMed Central, Scopus, Web of Science, Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS)
Experimental Pharmacology and Drug Discovery welcomes submissions of the following article types: Book Review, Brief Research Report, Correction, Data Report, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Protocols, Research Snapshot, Review, Specialty Grand Challenge and Technology Report.
All manuscripts must be submitted directly to the section Experimental Pharmacology and Drug Discovery, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Articles published in the section Experimental Pharmacology and Drug Discovery will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Pharmacology.
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