Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Review

Published on 07 Nov 2025

DNA methylation and immune regulation in osteoporosis: emerging epigenetic targets for drug discovery

in Experimental Pharmacology and Drug Discovery

Yingli Yang
Yao Yao
Xiaoyu Cai
Yaqi Tao
Zhengbing Zhuge
Jianhong Zhou
Caihong Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688305

268 views

Review

Published on 07 Nov 2025

Computational-aided drug design strategies for drug discovery and development against oral diseases

in Experimental Pharmacology and Drug Discovery

Tong Wu
Wentao Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678652

512 views

Original Research

Published on 07 Nov 2025

Nrf2-mediated mechanistic pathways of celastrol nephroprotection: disrupting the oxidative-inflammatory-apoptotic axis in cypermethrin toxicity

in Experimental Pharmacology and Drug Discovery

Ashraf Albrakati

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670444

397 views

Original Research

Published on 07 Nov 2025

Identifying gastric intestinal metaplasia risk based on clinical indicators: a machine learning predictive model based on the SHAP methodology

in Experimental Pharmacology and Drug Discovery

Yufen Wang
Jian Bi
Shunzhe Song
Ying Sun
Aixia Gong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602191

317 views

Original Research

Published on 07 Nov 2025

Bioassay-guided isolation of sesamin and fargesin from the hydroalcoholic stem extract of Zanthoxylum armatum DC. inhibited inflammation in CpG-stimulated conventional type 1 dendritic cells

in Experimental Pharmacology and Drug Discovery

Ningthoujam Indrajit Singh
Chayan Mukherjee
Jerina Soibam
Wangkheimayum Marjit Singh
Naresh Chandra Bal
Sunil Kumar Raghav
Chingakham Brajakishor Singh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1687789

299 views

Review

Published on 07 Nov 2025

Target fishing: from “needle in haystack” to “precise guidance”--new technology, new strategy and new opportunity

in Experimental Pharmacology and Drug Discovery

Juan Chen
Yafei Guo
Jing Shao
Mei Guo
Xinyu Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673688

372 views

Original Research

Published on 06 Nov 2025

Trehalose alleviates nephropathy in focal segmental glomerulosclerosis via the upregulation of the WT-1/EZH2 pathway

in Experimental Pharmacology and Drug Discovery

Maha Al-Asmakh
Marwa AL Riyami
Miytha Al Marbuii
Shadia Al Sinawi
Suaad Al-Badi
Faisal AL Ismaili
Amira AlKharusi
Razan Zadjali
Zaina Alharthi
Sara Al Mashrafi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1706617

354 views

Review

Accepted on 05 Nov 2025

Anticancer potential of natural bioactive compounds saponins in glioblastoma multiforme

in Experimental Pharmacology and Drug Discovery

Deena Elsori
Fahad Alshabrmi
Ahmed M. Alharbi
Mohd Saeed
Ajay Singh
Pratibha Pandey
Safia Obaidur Rab
Dr. Fahad Khan

Frontiers in Pharmacology

Correction

Accepted on 05 Nov 2025

A current review on animal models of anti-asthmatic drugs screening

in Experimental Pharmacology and Drug Discovery

Shivam Singh
Sunita Kularia
Shivakshi Shukla
Dr. Mithilesh Singh
Manish Kumar
Ashish Kumar Sharma

Frontiers in Pharmacology

238 views

Original Research

Published on 05 Nov 2025

HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway

in Experimental Pharmacology and Drug Discovery

Chelimuge Gong
Dalintai Wang
Qingshan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683575

410 views

Original Research

Accepted on 04 Nov 2025

Different degrees of expression pulmonary fibrosis signs with intratracheal administration of bleomycin at different doses to male SD rats (a study aimed at helping to select the optimal bleomycin dose for modeling pulmonary fibrosis)

in Experimental Pharmacology and Drug Discovery

Elena A. Tukhovskaya
Yulia A. Palikova
Maria S. Severyukhina
Alina M. Ismailova
Victor Palikov
Gulsara A. Slashcheva
Natalya Borozdina
Evgeniy S. Mikhaylov
Irina N. Kravchenko
Vitaly Kazakov

Frontiers in Pharmacology

Original Research

Accepted on 04 Nov 2025

Opioid-Free Anesthesia with Esketamine Combined with Interpectoral Plane Block and Pectoralis-Serratus Plane Blocks in Radical Mastectomy: A Randomized Controlled Trial

in Experimental Pharmacology and Drug Discovery

Wenping Ding
Youming Deng
Nuo Sun
Rongguo Wang
Qian Liu
Yan Zhang
Meiyan Zhou
Yan Liu
Liwei Wang

Frontiers in Pharmacology

130 views

Original Research

Accepted on 03 Nov 2025

Photodynamic therapy with a novel photosensitizer inhibits BLM-induced pulmonary fibrosis in mice via MRC1-mediated pathway

in Experimental Pharmacology and Drug Discovery

Ming hui Zhu
Nan Wang
Fei yu Zhang
Yu mei Rong
Zhen yu Zhao

Frontiers in Pharmacology

121 views

Original Research

Accepted on 03 Nov 2025

Pentoxifylline Vaginal Gel Improves Sperm Mo8lity and Vitality in Asthenozoospermic Males: A Randomized, Blinded, In Vitro Study

in Experimental Pharmacology and Drug Discovery

Cristina Trilla
Lidia Navarro
Mariona Rius
Juan José Espinós

Frontiers in Pharmacology

Original Research

Accepted on 03 Nov 2025

Safety profile of lutein-based blue dyes and surgical lights

in Experimental Pharmacology and Drug Discovery

Mario Romano
Federica Conti
Francesca Lazzara
Barbara Parolini
Mariantonia Ferrara
Claudio Bucolo

Frontiers in Pharmacology

173 views

Original Research

Published on 03 Nov 2025

Characterization of Androctonus mauritanicus venom and in vitro screening of SARS-CoV-2 entry inhibitors candidates

in Experimental Pharmacology and Drug Discovery

Reda Chahir
Jacob Galan
Hicham Hboub
Ahmed Salim Lahlou
Salma Chakir
Hinde Aassila
Reda Ben Mrid
Najat Bouchmaa
Reto Stöcklin
Rachid El Fatimy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678606

1,385 views