Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 30 May 2025

Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming

in Experimental Pharmacology and Drug Discovery

Haruki Watanabe
Tengfei Song
Jaewoo Choi
Moses Lee
Kwangmin Choi
Junhwan Kim
Barbara Sherry
Betty Diamond
Yong-Rui Zou
Myoungsun Son

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588987

Original Research

Published on 30 May 2025

Protective effects of shikimic acid against thioacetamide-induced hepatic fibrosis: role of Nrf2/NF-κB signaling pathways

in Experimental Pharmacology and Drug Discovery

Ashraf Albrakati

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609711

106 views

Original Research

Published on 30 May 2025

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism

in Experimental Pharmacology and Drug Discovery

Manhang Hu
Xiaolu Hua
Wei Xiong
Enhui Zheng
Xingyue Yang
Yu Lu
Bing He
Xiaolin Zhong
Zongzhe Jiang
Qingbi Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586141

Original Research

Published on 30 May 2025

Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia

in Experimental Pharmacology and Drug Discovery

Biyu Zhang
Denggang Fu
Xin Wang
Xuelei Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591164

Original Research

Published on 30 May 2025

Perfusion pressure as a determinant of respiratory function outcomes in unilateral biportal lumbar endoscopic procedures

in Experimental Pharmacology and Drug Discovery

Liang Zhang
Han Zheng
Yan Fu
Wenbo Li
Jianlong Lang
Yi Wang
Weibin Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1593118

151 views

Original Research

Published on 30 May 2025

7-α-O-Methylmorroniside ameliorated brain injury in 5×FAD mice by regulating the gut microbiome and NMDAR2B

in Experimental Pharmacology and Drug Discovery

Fengxiao Hao
Mengnan Zeng
Bing Cao
Xiwen Liang
Zhiyou Hao
Kaili Ye
Xinmian Jiao
Weisheng Feng
Xiaoke Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1545566

128 views

Original Research

Published on 30 May 2025

Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1

in Experimental Pharmacology and Drug Discovery

Yohan Seo
Sion Lee
Raju Das
Sung Baek Jeong
Chul Soon Park
Minuk Kim
Deok Kyu Yoon
Armin Sultana
Kantu Das
Jae-Eon Lee

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1557193

Original Research

Published on 30 May 2025

Multimodal endovascular management of traumatic carotid-cavernous fistulas: case series and lessons learned

in Experimental Pharmacology and Drug Discovery

Shangdi Yang
Richao Chen
Mingjia Yi
Chuangnan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602971

Correction

Accepted on 29 May 2025

Corrigendum:A telomere-related signature for predicting prognosis and immune microenvironment of osteosarcoma

in Experimental Pharmacology and Drug Discovery

Shihao Li
Lina Zhang
Haiyang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1600217

Review

Accepted on 29 May 2025

Potential of Functional Flavonoids in Targeting Vasospasm through Modulation of Oxidative Stress and SPC-induced Signaling Pathways

in Experimental Pharmacology and Drug Discovery

YING ZHANG
Sho Maejima
Kentaro Matsuzaki
Hiroko Kishi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1594060

Correction

Accepted on 29 May 2025

Neuroprotective effects of a novel peptide through the Rho-integrin-Tie2 and PI3K/Akt pathways in experimental autoimmune encephalomyelitis model

in Experimental Pharmacology and Drug Discovery

Wen Zhou
Han Qu
Xiao-Xiao Fu
Miao-Miao Xu
Qiang Li
Yuan Jiang
Shu Han

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1611105

Original Research

Published on 29 May 2025

Deep learning-based action recognition for analyzing drug-induced bone remodeling mechanisms

in Experimental Pharmacology and Drug Discovery

Li Qinsheng
Li Ming
Li Yuening
Zhao Xiufeng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564157

185 views

Correction

Accepted on 28 May 2025

Corrigendum: Optimized automated radiosynthesis of 18F-JNJ64413739 for purinergic ion channel receptor 7(P2X7R) imaging in osteoporotic model rats

in Experimental Pharmacology and Drug Discovery

Yingtong Lu
Yan Cui
Lu Hou
Yuanfang Jiang
Shang Jingjie
Lu Wang
Hao Xu
Weijian Ye
Yang Qiu
Bin Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633378

112 views

Original Research

Accepted on 28 May 2025

Design, synthesis and antiproliferative activity of novel colchicine derivatives: selective inhibition of melanoma cell proliferation

in Experimental Pharmacology and Drug Discovery

Puneet Kumar
Tusharika Kotra
Waseem I. Lone I Lone
Yassir Arfath
Harshita Tiwari
Ashutosh Kumar Shukla
Rayees Sheikh
Jasha Momo H Anal

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528235

Review

Accepted on 28 May 2025

Progress in Structure-Based Drug Development Targeting Chemokine Receptors

in Experimental Pharmacology and Drug Discovery

Jin Wang
Chen Qu
Peng Xiao
Sijin Liu
Yu-Qi Ping
Jin-Peng Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1603950

117 views

Original Research

Accepted on 27 May 2025

KETAMIR-2, A NEW MOLECULAR ENTITY AND NOVEL KETAMINE ANALOG

in Experimental Pharmacology and Drug Discovery

Itzchak Angel
Rita Perelroizen
Wendy Deffains
Florian Adraoui
Eddy Pichinuk
Erez Aminov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606976