Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 15 Jul 2025

Fucoxanthin inhibits the proliferation of MOLM13 cells by targeting AKT to disrupt glucose metabolism

in Experimental Pharmacology and Drug Discovery

Tingting Niu
Ying Chen
Mengmeng Sun
Cong Shi
Duobing Zou
Wei Wu
Yuzhan Chen
Juanjuan Chen
Haimin Chen
Guifang Ouyang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601281

128 views

Original Research

Accepted on 14 Jul 2025

Piperine Protects Against Cerebral Ischemic Injury by Regulating the Caspase-1-Mediated Pyroptosis Pathway

in Experimental Pharmacology and Drug Discovery

Jiayuan Lu
Xinwen Dai
Siyu Xi
Bo Wang
Peng Zhang
Xueyan Fu
Juan Liu
Yiwei ZHang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601873

Original Research

Accepted on 14 Jul 2025

Hemerocallis citrina Baroni leaf total phenol alleviates depressive-like behaviors via modulating "microbiota-gut-brain" axis in chronic unpredictable mild stress -induced rats

in Experimental Pharmacology and Drug Discovery

Yanping Wang
Yanjun Jia
Wanning Zhao
Yazhou Shao
Zeyu Zhang
Huiru Chen
Shuangxi Qian
Fangdi Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642515

Original Research

Published on 14 Jul 2025

MD-Syn: synergistic drug combination prediction based on a multidimensional feature fusion method and attention mechanisms

in Experimental Pharmacology and Drug Discovery

XinXin Ge
Yi-Ting Lee
Shan-Ju Yeh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564339

379 views

Original Research

Published on 14 Jul 2025

Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators

in Experimental Pharmacology and Drug Discovery

Brent Van Bosstraeten
Katrijn Boon
Max Van Hoof
Wim Dehaen
Martyna Szpakowska
Andy Chevigné
Dominique Schols
Steven De Jonghe
Tom Van Loy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631129

249 views

Review

Published on 14 Jul 2025

The role of osteocalcin in regulating the acute stress response

in Experimental Pharmacology and Drug Discovery

Ning Kang
Jie Huang
Xiaoguang Han
Zhengqian Li
Yi Yuan
Xiangyang Guo
Ning Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646558

290 views

Review

Accepted on 11 Jul 2025

Critical dysregulated signaling pathways in drug resistance: Highlighting the repositioning of mebendazole for cancer therapy

in Experimental Pharmacology and Drug Discovery

Amin Aliabadi
Seyed Zachariah Moradi
Sadaf Abdian
Sajad Fakhri
Javier Echeverria

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631419

216 views

Original Research

Accepted on 11 Jul 2025

Discovery of a Selective Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1B Inhibitor with Antiadipogenic and Anti-diabetic Activities

in Experimental Pharmacology and Drug Discovery

Sein Kang
Yoon-Ju Na
Kyoung Jin Choi
Won Hoon Jung
Areum Park
Jeonghui Im
Sung Bum Park
Byumseok Koh
Joo-Youn Lee
Kwang-Lae Hoe

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1645033

187 views

Perspective

Accepted on 11 Jul 2025

Looking Beyond Silybin: The Importance of Other Silymarin Flavonolignans

in Experimental Pharmacology and Drug Discovery

Michal Selc
Andrea Babelova

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637393

Original Research

Accepted on 11 Jul 2025

Modulation of gut microbiota by Gardeniae Fructus oil exerts TLR4/NF-κB/NLRP3 pathway-mediated antidepressant effects based on transcriptomics and fecal transplantation

in Experimental Pharmacology and Drug Discovery

YunZhong Chen
Man Han
Yujing Zhou
Xinyu Gao
Xixi Cheng
Ling Deng
Shilin Ji
Zhengheng Li
Yu Cai
Chunchao Yan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635897

131 views

Review

Accepted on 11 Jul 2025

MicroRNA: Unveiling Novel Mechanistic and Theranostic Pathways in Diabetic Cardiomyopathy

in Experimental Pharmacology and Drug Discovery

Akash De
Arnab Sarkar
Tanmoy Banerjee
Rudranil Bhowmik
Shuvam Sar
Md Adil Shaharyar
Sanmoy Karmakar
NILANJAN GHOSH

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613844

128 views

Original Research

Published on 11 Jul 2025

Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways

in Experimental Pharmacology and Drug Discovery

Qi He
Yu-Pei Chen
Chun Wu
Hongtan Wu
Fei Li
Mingyu Li
Fangfang Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584233

279 views

Systematic Review

Published on 11 Jul 2025

P2X7 receptor as a key player in pathological pain: insights into Neuropathic, inflammatory, and cancer pain

in Experimental Pharmacology and Drug Discovery

Pan Jiang
Cai Wang
Fajing Jia
Hua Wu
Haihu Hao
Shaoze Jing

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1585545

246 views

Original Research

Published on 11 Jul 2025

The GPR30 agonist G-1 promotes hair growth via Wnt/Hedgehog signaling in mice

in Experimental Pharmacology and Drug Discovery

Mayu Yamano
Yuto Yamanaka
Shota Nishikawa
Yuki Masujima
Ryuji Ohue-Kitano
Ikuo Kimura

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1570922

432 views

Original Research

Accepted on 10 Jul 2025

Honey-fried licorice decoction ameliorates atrial fibrillation susceptibility by inhibiting the NOX2-ROS-TGF-beta-1 pathway

in Experimental Pharmacology and Drug Discovery

Yu Qin
Hao Zhi
Xiang Wu
Zhiling Tang
Jialei Fu
Jingyan Wang
Xiaodong Chen
Xueting Cai
Jianping Shen
Peng Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595111

177 views

Original Research

Published on 10 Jul 2025

A diaryl urea derivative, SMCl inhibits cell proliferation through the RAS/RAF/MEK/ERK pathway in hepatocellular carcinoma

in Experimental Pharmacology and Drug Discovery

Yue Fu
Weiyue Fang
Fuqiang Qiu
Juncai Lai
Yangjin Xu
Bin Chen
Yang Li
Xiaohui Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605515

381 views