Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Systematic Review

Accepted on 18 Jun 2025

Efficacy and safety of stem cells in the treatment of glaucoma: systematic review and meta-analysis based on animal experiments

in Experimental Pharmacology and Drug Discovery

Danning Wu
Yanjing Liu
Xia Zhang
Ruixuan Zhang
Shaopeng Wang
Hui Lu
Tao Yue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1587440

Original Research

Published on 18 Jun 2025

Modified Zexie decoction improves phlegm-dampness type stage I hypertension by regulating the gut-immune-kidney axis

in Experimental Pharmacology and Drug Discovery

Zeqi Hu
Jiujie Jia
Yiyan Su
Yihao Gu
Bingbing Cheng
Ninghua Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578815

229 views

Original Research

Published on 18 Jun 2025

Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: a targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammation in rats

in Experimental Pharmacology and Drug Discovery

Elsayed A. Elmorsy
Sameh Saber
Zubida M. Al-Majdoub
Rabab S. Hamad
Mustafa Ahmed Abdel-Reheim
Asmaa Ramadan
Norah Suliman Alsoqih
Mariam S. Alharbi
Hamad Alsaykhan
Alshaimaa A. Farrag

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1546010

355 views

Original Research

Published on 18 Jun 2025

Eucommia ulmoides seed oil is a complementary food for suppressing digestive tumors

in Experimental Pharmacology and Drug Discovery

Jinzheng Wu
Liang Wen
Durairaj Karthick Rajan
Yan Liu
Xin Yang
Hao Jiang
Jinhua Yan
Bo Shu
Shubing Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564999

151 views

Original Research

Published on 18 Jun 2025

Structure-based discovery and experimental validation of HIT101481851 as a potential PKMYT1 inhibitor for pancreatic cancer

in Experimental Pharmacology and Drug Discovery

Ting Wang
Jingyu Wang
Gongxiong Yao
Hongchao Zhang
Chenghui Song
Xueren Ao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605741

215 views

Original Research

Accepted on 17 Jun 2025

From radiolabeling to receptor quantification: Preclinical assessment of [⁹⁹ᵐTc]Tc-carvedilol as a cardiac β-adrenoceptor probe

in Experimental Pharmacology and Drug Discovery

Hala F Azhari

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1581598

112 views

Original Research

Accepted on 17 Jun 2025

Myricetin Protects Against Doxorubicin-Induced Acute Kidney Injury in Rats by Mitigating Oxidative Damage and Apoptotic Response

in Experimental Pharmacology and Drug Discovery

Muhammed Talha Karadogan
Betul Cicek
Kagan Tolga Cinisli
Ali Sefa Mendil
Mustafa Ozkaraca
Furkan Yilmaz
Halis Suleyman

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601628

Original Research

Accepted on 17 Jun 2025

PolyLLM: Polypharmacy Side Effect Prediction via LLM-Based SMILES Encodings

in Experimental Pharmacology and Drug Discovery

Sadra Hakim
Alioune Ngom

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1617142

Original Research

Published on 17 Jun 2025

Decoding the therapeutic mechanism of Conocarpus lancifolius in hepatocellular carcinoma: network pharmacology, molecular docking, and LC-MS QTOF insights

in Experimental Pharmacology and Drug Discovery

Poojaben M. Prajapati
Saumya K. Patel
Rakesh M. Rawal
Komal G. Lakhani
Rasmieh Hamid
Bharat B. Maitreya

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1582374

569 views

Review

Accepted on 16 Jun 2025

Synthetic and semi-synthetic antioxidants in medicine and food industry: A review

in Experimental Pharmacology and Drug Discovery

Jan Tauchen
Lukáš Huml
Michal Jurášek
Joe M Regenstein
Fatih Ozogul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1599816

150 views

Original Research

Accepted on 16 Jun 2025

MT2 Receptor Mediates Melatonin-Induced Thermogenic Program in Human Myoblasts: Insights for Circadian Syndrome and Diabesity Treatment

in Experimental Pharmacology and Drug Discovery

DIEGO SALAGRE
Juan Sanjuán-Hidalgo
Ehab Kotb Elmahallawy
Pedro P Medina
Ahmad Agil

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633326

Editorial

Published on 13 Jun 2025

Editorial: Multi-target drug discovery and design for complex health disorders

in Experimental Pharmacology and Drug Discovery

Farid A. Badria
Barbara De Filippis
Mohammed Abu El-Magd
Mostafa M. Elbadawi
Abdelrahman Hamdi
Abdullah A. Elgazar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633600

377 views

Original Research

Published on 13 Jun 2025

The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota

in Experimental Pharmacology and Drug Discovery

Lixuan Yang
Yutian Ao
Yannan Li
Baoan Dai
Junnan Li
Wenzhe Duan
Kaiqiang Dong
Zhenyun Han
Rongjuan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510250

278 views

Review

Published on 13 Jun 2025

Lactate-induced lactylation: from basic research to clinical perspectives

in Experimental Pharmacology and Drug Discovery

Henghe Shi
Yifei Zou
Sijie Jin
Junduo Wu
Bin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586973

354 views

Original Research

Published on 13 Jun 2025

Reversal of ABCG2-mediated drug resistance by tinodasertib (ETC-206)

in Experimental Pharmacology and Drug Discovery

Haigan Yang
Zheshen Li
Zhuoxun Wu
Xiang Chen
Letao Bo
Harsh Patel
Bohan Zhang
Wenjun Xiong
Wei Wang
Zhe-Sheng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606857

260 views

Original Research

Accepted on 12 Jun 2025

Interaction of Blood-Entry Components, Network Pharmacology and Transcriptomics to Elucidate the Mechanism of Wentong Plaster in Treating Primary Dysmenorrhea

in Experimental Pharmacology and Drug Discovery

Zongtong Yang
Ziqi Jiao
Cheng Wang
Xiaojing Li
Mengyu Yuan
Zaiyun Sui
Wenhui Wang
Wenjing Hou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1591558

101 views