Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 18 Jul 2025

Effects of realgar-indigo naturalis formula on a zebrafish tumor xenograft model induced by human acute promyelocytic leukemia cells: antitumor activity, hepatotoxicity, and transcriptomic analysis

in Experimental Pharmacology and Drug Discovery

Donghan Bai
Zihao Zhang
Jingyue Gao
Qiaochu Wang
Remy Macdonald
Ziwen Xu
Shumin Chen
Nanxi Huang
Lu Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1619352

146 views

Review

Accepted on 17 Jul 2025

The effects of cynaroside on lipid metabolism and lipid-related diseases: a mechanistic overview

in Experimental Pharmacology and Drug Discovery

Chenyi Cen
Jiahuan Li
Pu Zhou
David Fisher
Nguyen Thi Thu Hien
Erkin Musabaev
Khrystyna Pronyuk
Lei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648614

Original Research

Accepted on 17 Jul 2025

Luteolin attenuates inflammation and apoptosis in LPS-induced ALI mice by activating the HGF/c-Met pathway

in Experimental Pharmacology and Drug Discovery

Jihong Bi
Yan Li
Lin Lu
Tingting Yin
Shaohua Mao
Run Zhang
Juan He
Xing Ni
Kai Wang
Jirui Bi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641486

Review

Accepted on 17 Jul 2025

Machine Learning-Based Drug-Drug Interaction Prediction: A Critical Review of Models, Limitations, and Data Challenges

in Experimental Pharmacology and Drug Discovery

Flaviu-Ioan Gheorghita
Vlad-Ioan Bocanet
Laszlo Barna Iantovics

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1632775

153 views

Original Research

Published on 17 Jul 2025

Improving synergistic drug combination prediction with signature-based gene expression features in oncology

in Experimental Pharmacology and Drug Discovery

Mozhgan Mozaffarilegha
Sajjad Gharaghani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614758

182 views

Original Research

Published on 17 Jul 2025

Uncovering the molecular mechanisms of Qingdu Zengye Decoction in the treatment of nasopharyngeal carcinoma: an integrative investigation

in Experimental Pharmacology and Drug Discovery

Qi Quan
Zeyu Liu
Ran Ding
Yongmiao Lin
Sihe Zhang
Wei Luo
Mengjie Lei
Teng Fan
Xin Su
Yuanyuan Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648294

199 views

Original Research

Published on 17 Jul 2025

Machine learning-enhanced discovery of tsRNA-mRNA regulatory networks: identifying novel diagnostic biomarkers and therapeutic targets in breast cancer

in Experimental Pharmacology and Drug Discovery

Zhongling Ma
Rui Wang
Ming Yuan
Bo Wang
Li Li
Tianfu Zhao
Xinhan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640192

271 views

Original Research

Published on 17 Jul 2025

An immunomodulatory photosensitizer-mediated photodynamic therapy synergizes with PD-L1 blockade against metastatic triple-negative breast cancer

in Experimental Pharmacology and Drug Discovery

Yuetong Liu
Liming Wang
Feiyan Kong
Tianjun Liu
Hong Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651165

410 views

Systematic Review

Published on 16 Jul 2025

Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials

in Experimental Pharmacology and Drug Discovery

Dangzhen Liu
Haiyan Zhao
Yiwen Zhang
Jingqing Hu
Hong Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1572197

490 views

Original Research

Published on 16 Jul 2025

Prognostic value of the pre-treatment albumin-to-alkaline phosphatase ratio in patients with lower-grade glioma: a propensity score matching study

in Experimental Pharmacology and Drug Discovery

Xiaoming Huang
Lingjuan Li
Di Zang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1556108

265 views

Original Research

Accepted on 15 Jul 2025

Discovery of novel and potent celastrol derivatives as PRDX1 inhibitors for cancer therapy through structure-based virtual screening

in Experimental Pharmacology and Drug Discovery

Lixia Guan
Yifei Geng
Yuting Wang
Miao-Miao Niu
Kun Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625604

Original Research

Published on 15 Jul 2025

Fucoxanthin inhibits the proliferation of MOLM13 cells by targeting AKT to disrupt glucose metabolism

in Experimental Pharmacology and Drug Discovery

Tingting Niu
Ying Chen
Mengmeng Sun
Cong Shi
Duobing Zou
Wei Wu
Yuzhan Chen
Juanjuan Chen
Haimin Chen
Guifang Ouyang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601281

293 views

Original Research

Accepted on 14 Jul 2025

Piperine Protects Against Cerebral Ischemic Injury by Regulating the Caspase-1-Mediated Pyroptosis Pathway

in Experimental Pharmacology and Drug Discovery

Jiayuan Lu
Xinwen Dai
Siyu Xi
Bo Wang
Peng Zhang
Xueyan Fu
Juan Liu
Yiwei ZHang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601873

102 views

Original Research

Accepted on 14 Jul 2025

Hemerocallis citrina Baroni leaf total phenol alleviates depressive-like behaviors via modulating "microbiota-gut-brain" axis in chronic unpredictable mild stress -induced rats

in Experimental Pharmacology and Drug Discovery

Yanping Wang
Yanjun Jia
Wanning Zhao
Yazhou Shao
Zeyu Zhang
Huiru Chen
Shuangxi Qian
Fangdi Hu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642515

Original Research

Published on 14 Jul 2025

MD-Syn: synergistic drug combination prediction based on a multidimensional feature fusion method and attention mechanisms

in Experimental Pharmacology and Drug Discovery

XinXin Ge
Yi-Ting Lee
Shan-Ju Yeh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1564339

497 views

Original Research

Published on 14 Jul 2025

Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators

in Experimental Pharmacology and Drug Discovery

Brent Van Bosstraeten
Katrijn Boon
Max Van Hoof
Wim Dehaen
Martyna Szpakowska
Andy Chevigné
Dominique Schols
Steven De Jonghe
Tom Van Loy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1631129

342 views