Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 10 Sep 2026

Advanced hybrid-stabilized cinacalcet nanocrystals for enhanced oral bioavailability: formulation and integrated in vitro/in vivo evaluations

in Experimental Pharmacology and Drug Discovery

Rawan Gamal Eldin
Salma M. Mosleh
Osama Saher
Sadek Ahmed
Ahmed M. Fatouh

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1904508

534 views

Original Research

Accepted on 09 Sep 2026

Safety Assessment of a Mitragyna speciosa Leaf Extract by a 90-day Feeding Study in Rats

in Experimental Pharmacology and Drug Discovery

Paula Naomi Brown
Michael Chan

Frontiers in Pharmacology

Review

Published on 09 Sep 2026

Artificial intelligence-driven drug discovery: a deep learning paradigm shift in pharmaceutical research and development

in Experimental Pharmacology and Drug Discovery

Xueyuan Bi
Yangyang Wang
Jihan Wang
Cuicui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1927954

336 views

Brief Research Report

Published on 09 Sep 2026

Exploratory proteomic characterization of Apis mellifera venom across an environmental gradient in central Chile

in Experimental Pharmacology and Drug Discovery

José Luis Marcos
Ricardo Campos-Soto
Rina Ortiz
Yerko Olivares
Joan Villena
Mario Párraga
Ramón Sotomayor-Zárate
Luis Constandil
Heine Müller

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1904856

270 views

Review

Published on 09 Sep 2026

Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation

in Experimental Pharmacology and Drug Discovery

Amedeo Amedei
Cinzia Parolini

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1905572

269 views

Original Research

Accepted on 08 Sep 2026

In vitro pharmacological profiling of ITE amide bioisosteric aryl hydrocarbon receptor agonist

in Experimental Pharmacology and Drug Discovery

Zdenek Dvorak
Aneta Grycova
Radim Vrzal
Miroslav Soural
Iveta Zuvalova
Jakub Přikryl

Frontiers in Pharmacology

Original Research

Accepted on 08 Sep 2026

P2X7 receptor contributes to hepatic inflammation and collagen deposition in methionine- and choline-deficient diet-fed mice

in Experimental Pharmacology and Drug Discovery

Sthefani Silva
Fabiana Cristina Rodrigues
Mariana M. Chaves
Isabele Pinheiro Cruz
Lorraine de Oliveira da Cruz
Maria Fernanda Carvalho de Araujo
Soraia das Neves Vieira Cavalcanti
Georgia Correa Atella
Christina Maeda Takiya
Luiz Eduardo Baggio Savio

Frontiers in Pharmacology

Mini Review

Accepted on 08 Sep 2026

Tryptophan metabolism circadian regulation: clinical and pharmacological implications

in Experimental Pharmacology and Drug Discovery

Consuelo Fabi
Sarah Balucchi
Marina Maria Bellet

Frontiers in Pharmacology

Original Research

Published on 08 Sep 2026

Treatment of neuropathic pain in diabetic rats with synergistic combinations of nortriptyline + tramadol and nortriptyline + ibuprofen

in Experimental Pharmacology and Drug Discovery

M. Gicela Pérez-Hernández
Alberto Sesena-Rubfiaro
Ángel D. Trillo-Arenazas
Yolitzy Cárdenas
Miguel Huerta
Xóchitl Trujillo
Enrique A. Sánchez-Pastor
M. Irene Díaz-Reval

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1814008

519 views

Original Research

Accepted on 07 Sep 2026

Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M® and a HaCaT-based epidermal construct

in Experimental Pharmacology and Drug Discovery

Filipi Dugonik
Urška Jeršič
Lejla Kač
Lidija Gradisnik
Tanja Zidarič
Uroš Maver
Tina Maver

Frontiers in Pharmacology

Brief Research Report

Accepted on 07 Sep 2026

5-HT2A RECEPTOR ACTIVATION INDUCES CB1-DEPENDENT PRESYNAPTIC INHIBITORY LONG-TERM DEPRESSION IN THE NUCLEUS ACCUMBENS CORE

in Experimental Pharmacology and Drug Discovery

Camila Estay-Olmos
Koyam Morales-Weil
Juan Ahumada
Ramón Sotomayor-Zárate
Marco Fuenzalida

Frontiers in Pharmacology

Original Research

Accepted on 07 Sep 2026

Protective Effects of Cannabidiol against Acute Stress: Behavioral Responses and Corticosterone Concentrations in Female Wistar Rats

in Experimental Pharmacology and Drug Discovery

Matjaž Uršič
Mina Cansu Karaer
Alenka Gregorič
Tilen Vake
Tomaž Snoj

Frontiers in Pharmacology

Original Research

Accepted on 07 Sep 2026

Anti-Nectin4 monoclonal antibodies attenuate airway inflammation and epithelial barrier dysfunction in asthma

in Experimental Pharmacology and Drug Discovery

Pureun-Haneul Lee
MinHyeok An
SangMin Yoon
An-Soo Jang

Frontiers in Pharmacology

Correction

Published on 07 Sep 2026

Correction: Novel PE-DT-fusion toxin enhances internalization and target-dependently restores the cytotoxicity of recombinant immunotoxins

in Experimental Pharmacology and Drug Discovery

Claudia Fischer
Kerstin Wendland
Anna Ammon
Franziska Gsottberger
Lisa Mellenthin
Srdjan Petkovic
Andreas Mackensen
Fabian Müller

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1979795

286 views

Brief Research Report

Accepted on 04 Sep 2026

Online Adaptive E-tutorials for Development of Critical Appraisal Skills

in Experimental Pharmacology and Drug Discovery

Loyola McLean
Samuel Lane
Erick C.N. Wong
Louise Nash
Eryn L Werry

Frontiers in Pharmacology

Original Research

Published on 04 Sep 2026

LP533401 treatment alters vitamin K metabolism, bone Gla-OC/Glu-OC ratios, and improves mineral status of the skeleton in rats with chronic kidney disease

in Experimental Pharmacology and Drug Discovery

Magdalena Kopańko
Beata Sieklucka
Dariusz Pawlak
Magdalena Zabłudowska
Katarzyna Sokołowska
Urszula Łebkowska
Krystyna Pawlak

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1793663

402 views

Review

Published on 04 Sep 2026

Optimization of next-generation CXCR4 ligands for radiotheranostic applications

in Experimental Pharmacology and Drug Discovery

Itzel Reneé Astiazarán-Rascón
Joseph Lau
François Bénard

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1923347

406 views

Correction

Accepted on 03 Sep 2026

Correction: Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells

in Experimental Pharmacology and Drug Discovery

Keyi Lu
Yuanyuan Wang
Yifan Shi
Siqi Liu
Yanna Shao
Zhibin Wang
Erping Xu

Frontiers in Pharmacology

Original Research

Published on 03 Sep 2026

Quantitative characterization of L-citrulline as a precursor of L-arginine in rats: pharmacokinetic basis for nitric oxide-mediated effects

in Experimental Pharmacology and Drug Discovery

Sungmin Song
Subindra Kazi Thapa
Mahesh Upadhyay
Seonwoo Yang
Taesun Kim
Seung-Dong Yoo
Beom Soo Shin
Soyoung Shin

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1889835

1,735 views

Original Research

Published on 01 Sep 2026

GPER and EGFR cross-talk highlight aldosterone- and MR antagonist-induced NO production in cultured endothelial cells

in Experimental Pharmacology and Drug Discovery

Renata Paredes
M. Verónica Donoso
Carlos F. Lagos
César Cárdenas
Claudio Acuña-Castillo
Daniel Valdes
Luis Constandil
Juan Pablo Huidobro-Toro

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1891002

525 views

Original Research

Published on 01 Sep 2026

Effects of HA1, a probucol analogue, and APOC3 siRNA on lipoprotein and amyloid-β metabolism and neurovascular dysfunction in type 2 diabetic mice

in Experimental Pharmacology and Drug Discovery

Arazu Sharif
John Charles Louis Mamo
Virginie Lam
Giuseppe Luna
Gerald F. Watts
Michael Leo Nesbit
Hani Al-Salami
Armin Mooranian
Ryusuke Takechi

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1826957

1,106 views

Review

Accepted on 31 Aug 2026

From Molecular Correction to Functional Rescue: Delivery, Tissue State, and Immunobiology as the Principal Constraints on Dystrophin-Restoring Therapy in Duchenne Muscular Dystrophy

in Experimental Pharmacology and Drug Discovery

Ke Li
Huan Qi
Yaoyao Xin
Lun Qin
Yulong Cheng
Xin Yao

Frontiers in Pharmacology

1,194 views

Original Research

Accepted on 31 Aug 2026

microRNA-15b modulates stress-induced premature senescence and secretory phenotypes in chronic doxorubicin cardiomyopathy

in Experimental Pharmacology and Drug Discovery

Georthan Mancilla
Clara Quiroga
Pablo Castro
Ivonne Olmedo
Hugo Verdejo
Zully Pedrozo

Frontiers in Pharmacology

100 views

Original Research

Accepted on 31 Aug 2026

Alda-1 Reduces Chronic and Post-Deprivation Nicotine Intake in Rats: Impact of Concurrent Ethanol Consumption on Treatment Efficacy

in Experimental Pharmacology and Drug Discovery

Fresia Solís-Egaña
Sofía Adasme-Reyes
Ignacio Gutiérrez Vega
María Elena Quilaqueo
María Elena Quintanilla
David Vásquez
Mario Herrera-Marschitz
Paola Morales Retamales
Mario Rivera-Meza

Frontiers in Pharmacology

111 views

4,137 articles

articles

Advanced hybrid-stabilized cinacalcet nanocrystals for enhanced oral bioavailability: formulation and integrated in vitro/in vivo evaluations

Safety Assessment of a Mitragyna speciosa Leaf Extract by a 90-day Feeding Study in Rats

Artificial intelligence-driven drug discovery: a deep learning paradigm shift in pharmaceutical research and development

Exploratory proteomic characterization of Apis mellifera venom across an environmental gradient in central Chile

Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation

In vitro pharmacological profiling of ITE amide bioisosteric aryl hydrocarbon receptor agonist

P2X7 receptor contributes to hepatic inflammation and collagen deposition in methionine- and choline-deficient diet-fed mice

Tryptophan metabolism circadian regulation: clinical and pharmacological implications

Treatment of neuropathic pain in diabetic rats with synergistic combinations of nortriptyline + tramadol and nortriptyline + ibuprofen

Barrier model selection alters apparent diclofenac permeation parameters: a controlled in vitro comparison of Strat-M® and a HaCaT-based epidermal construct

5-HT2A RECEPTOR ACTIVATION INDUCES CB1-DEPENDENT PRESYNAPTIC INHIBITORY LONG-TERM DEPRESSION IN THE NUCLEUS ACCUMBENS CORE

Protective Effects of Cannabidiol against Acute Stress: Behavioral Responses and Corticosterone Concentrations in Female Wistar Rats

Anti-Nectin4 monoclonal antibodies attenuate airway inflammation and epithelial barrier dysfunction in asthma

Correction: Novel PE-DT-fusion toxin enhances internalization and target-dependently restores the cytotoxicity of recombinant immunotoxins

Online Adaptive E-tutorials for Development of Critical Appraisal Skills

LP533401 treatment alters vitamin K metabolism, bone Gla-OC/Glu-OC ratios, and improves mineral status of the skeleton in rats with chronic kidney disease

Optimization of next-generation CXCR4 ligands for radiotheranostic applications

Correction: Celastrol ameliorates ulcerative colitis by inhibiting HSP90-mediated necroptosis of intestinal epithelial cells

Quantitative characterization of L-citrulline as a precursor of L-arginine in rats: pharmacokinetic basis for nitric oxide-mediated effects

GPER and EGFR cross-talk highlight aldosterone- and MR antagonist-induced NO production in cultured endothelial cells

Effects of HA1, a probucol analogue, and APOC3 siRNA on lipoprotein and amyloid-β metabolism and neurovascular dysfunction in type 2 diabetic mice

From Molecular Correction to Functional Rescue: Delivery, Tissue State, and Immunobiology as the Principal Constraints on Dystrophin-Restoring Therapy in Duchenne Muscular Dystrophy

microRNA-15b modulates stress-induced premature senescence and secretory phenotypes in chronic doxorubicin cardiomyopathy

Alda-1 Reduces Chronic and Post-Deprivation Nicotine Intake in Rats: Impact of Concurrent Ethanol Consumption on Treatment Efficacy