Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Mini Review

Published on 17 Oct 2025

Leveraging artificial intelligence to validate traditional biomarkers and drug targets in liver cancer recovery: a mini review

in Experimental Pharmacology and Drug Discovery

Shengjian Wu
Xiaoqiao Chen
Yuxiu Ji
Chi Zhang
Yujie Xie
Bin Liang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697608

325 views

Original Research

Published on 17 Oct 2025

Artemisinin exerts antidepressant-like effects via activation of AKT and ERK signaling pathways

in Experimental Pharmacology and Drug Discovery

Ruohong Lin
Zhiwei Zhou
Yizhou Jiang
Song Liu
Jinfeng Xie
Haitao Wang
Henning Ulrich
Wenhua Zheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1642167

555 views

Original Research

Published on 17 Oct 2025

Alpha-ketoglutarate rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice

in Experimental Pharmacology and Drug Discovery

Jing-Hui Qiu
Xiao-Bao Ruan
Yu Jiang
Wen-Ting Shi
Xia Tao
Alex F. Chen
Cheng Peng
He-Hui Xie

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656473

223 views

Systematic Review

Published on 17 Oct 2025

Cannabis and cannabinoids in dermatology: a systematic review and meta-analysis of quantitative outcomes

in Experimental Pharmacology and Drug Discovery

Pim Sermsaksasithorn
Tanawin Nopsopon
Chatpol Samuthpongtorn
Korn Chotirosniramit
Krit Pongpirul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609667

1,814 views

Editorial

Accepted on 16 Oct 2025

Editorial: Advancing Drug Discovery with AI: Drug–Target Interactions, Mechanisms of Action, and Screening

in Experimental Pharmacology and Drug Discovery

Xutong Li
Jing Xing
Sulin Zhang
Jiayu Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721323

224 views

Review

Accepted on 15 Oct 2025

Molecular docking and dynamics in protein serine/threonine kinase drug discovery: Advances, challenges, and future perspectives

in Experimental Pharmacology and Drug Discovery

Gulam Mustafa Hasan
Taj Mohammad
Sobia Zaidi
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1696204

Original Research

Published on 15 Oct 2025

β-Sitosterol attenuates obstructive sleep apnea-related myocardial injury via MALAT1-mediated HIF-1α regulation

in Experimental Pharmacology and Drug Discovery

Runhua Wu
Naijie Chen
Jingyi Li
Dan Liu
Feng Wang
Qin Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692758

293 views

Mini Review

Published on 15 Oct 2025

Biotechnological production of terpenoids using cell factories

in Experimental Pharmacology and Drug Discovery

Yalan Si
Shasha Li
Chen Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1621406

299 views

Review

Published on 15 Oct 2025

Decoding the structural and functional diversity of GABAA receptors: from ensemble logic to therapeutic opportunities

in Experimental Pharmacology and Drug Discovery

Mario Treviño
Magdalena Guerra-Crespo
Francisco J. Padilla-Godínez
Luis O. Soto-Rojas
Elías Manjarrez
Emmanuel Ortega-Robles
Julieta Rodríguez-de Ita
Oscar Arias-Carrión

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697905

657 views

Original Research

Published on 15 Oct 2025

Mass spectrometry-guided discovery of novel GCPII inhibitor scaffolds

in Experimental Pharmacology and Drug Discovery

Robyn Wiseman
Ajit G. Thomas
John Janiszewski
Nate Hoxie
Chae Bin Lee
Ying Wu
Takashi Tsukamoto
Lin Ye
Michael Ronzetti
Jonathan H. Shrimp

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646207

552 views

Original Research

Accepted on 14 Oct 2025

Modulatory Efficacy of Bone Metabolism and Safety of Denosumab versus Zoledronic Acid in the Treatment of Bone and Joint Osteoporosis in Elderly Men

in Experimental Pharmacology and Drug Discovery

Jing He
Yuhui Mao
Wanran Gong
Haitao Zhu
Peng Xiang
Shui Wang
Xiaofeng Dai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1666421

163 views

Opinion

Accepted on 14 Oct 2025

Drug Repurposing of Natural Depsipeptide from Eleftheria terrae Isolated via iChip for Anti-Breast Cancer Therapy

in Experimental Pharmacology and Drug Discovery

Nuriyatul Fhatonah
Tedi Rustandi
Usama Ramadan Abdelmohsen
La Ode Akbar Rasydy
Ma'sum Ma'sum
Yomna Elghanam
Imran Pashar
Nordin Nordin
Ahmed Mahal
Akhmad Riski

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694322

Original Research

Published on 14 Oct 2025

Network pharmacology and molecular docking analyses of the Wuwei Mingmu formula indicate that IL-10 and IL-6 are critical targets against experimental autoimmune uveitis in rats

in Experimental Pharmacology and Drug Discovery

Xing Liang
Junkun Zhang
Fang Yuan
Li Liang
Jie Li
Yajian Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614561

554 views

Review

Published on 14 Oct 2025

Recent progress in the development of etomidate analogues

in Experimental Pharmacology and Drug Discovery

Yanting Chen
Lan Wu
Bingchen Lang
Wensheng Zhang
Shouming Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614865

350 views

Original Research

Published on 14 Oct 2025

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

in Experimental Pharmacology and Drug Discovery

Zhuo Song
Xiuci Yan
Xiaohao Xu
Tingting Lou
Yu Wang
Limei Ren
Fangbing Liu
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657436

888 views

Editorial

Published on 14 Oct 2025

Editorial: Drug discovery for leishmaniasis and chagas disease: compound design and therapeutic strategies

in Experimental Pharmacology and Drug Discovery

Karunakaran Kalesh
Euzébio Guimarães Barbosa
Alessandro Kappel Jordão

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718438

421 views