Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Review

Accepted on 05 Sep 2025

Management of diabetic foot ulcers: polyherbal formulations and novel delivery systems for herbal active components

in Experimental Pharmacology and Drug Discovery

Bowen Feng
Jin Jin Dou
YiHan Wang
Changmei Wu
Xiaodong Lan
Yi Su
Xiwu Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1648540

2,787 views

Review

Accepted on 05 Sep 2025

Betulinic Acid and Obesity-Related Disorders

in Experimental Pharmacology and Drug Discovery

Lara Azevedo
Ricardo Ferraz
Mónica Vieira
Cristina Prudêncio
Sílvia Fernandes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674713

223 views

Systematic Review

Published on 05 Sep 2025

Drugs targeting the NO-sGC-cGMP pathway in the treatment of patients with COPD-associated pulmonary hypertension: a systematic review

in Experimental Pharmacology and Drug Discovery

Abdullah A. Alqarni
Sara A. Alghamdi
Abdulelah M. Aldhahir
Jaber S. Alqahtani
Rayan A. Siraj
Ahmed H. Alasimi
Heba M. Bintalib
Abdulkareem A. AlGarni
Mansour Majrshi
Adel M. Alshabasy

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1641932

593 views

Original Research

Published on 05 Sep 2025

Pinostilbene inhibits lung epithelial-mesenchymal transition and delays pulmonary fibrosis by modulating the PI3K/Akt pathway

in Experimental Pharmacology and Drug Discovery

Xin Yu
Li Xiao
Jiang Zhu
Tianying Sun
Kai Gong
Xuefang Kou
Yuhe Zhou
Mengzhen Xu
Kaihui Lu
Hua Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614546

827 views

Mini Review

Published on 05 Sep 2025

COPZ1: an example of non-oncogene addiction in human tumors

in Experimental Pharmacology and Drug Discovery

Tiziana Di Marco
Debora Vergaro
Angela Greco

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1636326

381 views

General Commentary

Accepted on 04 Sep 2025

Commentary: The Flexibility of SABRE, a New Quantitative Receptor Function Model, When Fitting Challenging Concentration-Effect Data

in Experimental Pharmacology and Drug Discovery

Peter Buchwald

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675039

200 views

Original Research

Accepted on 04 Sep 2025

In Vitro Antiproliferative Potential of Essential Oil Extract from Carica papaya L. Seeds Against Cervical Cancer

in Experimental Pharmacology and Drug Discovery

Doaa Sayed
Sally A Abdel-Halim
Mohamed-Elamir F Hegazy
Salwa Aljohani
Aljazi Abdullah Alrashidi
Mohamed A El-Desouky
Hoda A. Ahmed
Mariusz Jaremko
Abdul-Hamid Emwas
Demiana Hanna

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1676006

216 views

General Commentary

Published on 04 Sep 2025

Commentary: Blood metabolites as mediators in erectile dysfunction: insights from a multi-center proteomics and genetic study

in Experimental Pharmacology and Drug Discovery

Zhihao Huang
Hongxing Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1650398

310 views

Original Research

Published on 04 Sep 2025

Stearyl amine-modified elastic cerosomes for boosting the anti-cancer activity of albendazole

in Experimental Pharmacology and Drug Discovery

Rofida Albash
Hassan M. E. Azzazy
Shaimaa Mosallam
Mohammed I. A. Hamed
Khaled M. Darwish
Maha M. Abdel-Fattah
Lama A. Alshabani
Einas M. Yousef
Heba Mohammed Refat M. Selim
Ghadeer El-Fadaly

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595177

727 views

Original Research

Accepted on 03 Sep 2025

Nrf2 Activation by Celastrol in Nephrotoxicity Nrf2-Mediated Mechanistic Pathways of Celastrol Nephroprotection: Disrupting the Oxidative-Inflammatory-Apoptotic Axis in Cypermethrin Toxicity

in Experimental Pharmacology and Drug Discovery

Ashraf Albrakati

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670444

187 views

Original Research

Published on 03 Sep 2025

A novel scorpine-like peptide from the amazonian scorpion Brotheas amazonicus with cytolytic activity

in Experimental Pharmacology and Drug Discovery

Mouzarllem Barros Reis
Karla De Castro Figueiredo Bordon
Jonas Gama Martins
Gisele Adriano Wiezel
Ualter Guilherme Cipriano
Rudi Emerson de Lima Procópio
Vania Luiza Deperon Bonato
Eliane Candiani Arantes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1652614

766 views

Original Research

Published on 02 Sep 2025

Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins

in Experimental Pharmacology and Drug Discovery

Yunus Aksüt
Aslıhan Şengelen
Dudu Melek Gürsoy
İrem Öğütcü
Özge Kuvet
Murat Pekmez

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1643186

448 views

Original Research

Published on 02 Sep 2025

Oral administration of Ketamir-2, a novel ketamine analog, attenuates neuropathic pain in rodent models via selective NMDA antagonism

in Experimental Pharmacology and Drug Discovery

Itzchak Angel
Rita Perelroizen
Eddy Pichinuk
Erez Aminov

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1650926

470 views

Original Research

Accepted on 01 Sep 2025

Biosynthesized Zinc Oxide Nanoparticles from Cycas revoluta Seed Extract Demonstrate Significant Wound Healing, Antimicrobial, Antioxidant, and Cytotoxic Potential

in Experimental Pharmacology and Drug Discovery

Hajr Al-Wadei
Shifhali Morabad
Uday M Muddapur
Abdulrahman Manaa Alamri
Bader Aldoah
Adel Moalwi
Nasser A. N. Alzerwi
Saeed Alsareii
Mater Mahnashi
Ibrahim Ahmed Shaikh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605717

296 views

Original Research

Published on 01 Sep 2025

Synergistic antiallodynic effects of pregabalin and thioctic acid in a rat model of neuropathic pain

in Experimental Pharmacology and Drug Discovery

Edith Zárate
Vinicio Granados-Soto
Oscar Arias-Carrión

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1675015

492 views

Review

Published on 01 Sep 2025

Unveiling the therapeutic potential of caudatin: Structural optimization, pharmacological mechanisms, and therapeutic implications

in Experimental Pharmacology and Drug Discovery

Guohui Shi
Linlin Ni
Xiaoni Kong
Rutong Ren
Xinyu Shi
Yang Xu
Zhizi Qu
Honglei Zhou
Xiusheng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1640365

252 views