MINI REVIEW article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
This article is part of the Research TopicInsights into Solar Radiation: Therapeutic targets and Innovative productsView all articles
Effect of plant-derived exosome-like nanoparticles in ultraviolet-induced skin photoaging
Provisionally accepted
- Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
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Long-term exposure to ultraviolet (UV) irradiation leads to skin photoaging. The mechanism of photoaging is complex, involving oxidative stress, inflammation, and collagen degradation. Certain active ingredients derived from plants possess strong antioxidant and anti-inflammatory properties and have been utilized in cosmeceuticals for cosmetic medicine. Plant-derived exosome-like nanovesicles (PELNs) contain bioactive constituents obtained from plant cells, which contribute to PELNs possessing multiple pharmacological functions, making them beneficial to skin care. Some researchers used PELNs as natural agents to attenuate UVB-induced skin photoaging, and their findings are critical for discovering novel anti-photoaging treatment modalities. In this mini-review, we focus on the related research of PELNs and UVB-induced skin photoaging, and introduce the protective role of PELNs. Finally, we will discuss the challenges and future directions in the development of PELNs for anti-photoaging.
Keywords: Ultraviolet, Photoaging, Oxidative Stress, Inflammation, Plant-derivedexosome-like nanovesicles
Received: 10 Oct 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Dong, Deng, Li, Lin, Luo and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yangyan Luo
Yuan Jiang
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