Targeted Gene and Drug Delivery: Utilizing Cell Penetrating Peptides, Peptide Nucleic Acids, or Antibody/Receptor Mediated Delivery

Targeted delivery of potential therapeutics to organs, and even cell types in an organ, of interest has been the subject of intense research for decades. Although not perfected, these research efforts are beginning to bear fruit resulting in novel therapeutics coming into clinical use. There are multiple competing methods of targeted delivery that are being developed. This special issue aims to bring cutting edge research in this arena to its readers.

Our goal is to provide comprehensive review articles, as well as original, unpublished, research to the forefront encompassing cell penetrating peptides, peptide nucleic acids, or antibody targeted delivery. Original or review articles high-lighting techniques for enhancing serum stabilities, endosomal escape solutions, study of associated immune reactions, or enhancing targeted delivery are welcomed. We would also consider studies comparing these delivery vectors to other modalities including though not limited to viral vectors, lipid nanoparticles, including liposomes. We are particularly interested in targeted drug delivery to the heart, vessels, brain, skeletal muscles, liver, lung, pancreas, and kidney.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Targeted delivery, Viral vectors, Cell penetrating peptides, Liposomes, Nanoparticles, Lipid nanoparticles, Peptide nucleic acids, Antibody-mediated delivery

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.