About this Research Topic
The 10th International Society for Neurovascular Diseases (ISNVD) annual meeting will be held at New York University Grossman School of Medicine in September 2020, with topics themed around targeting the vascular contributions to age-related neurodegenerative diseases and cognitive impairment. ISNVD is a nonprofit professional association devoted to furthering the development of research in neurovascular, neurodegenerative and neuropsychiatric diseases that are related to both intra- and extra-cranial vascular abnormalities. In order to promote this conference event, ISNVD is collaborating with Frontiers in Neurology on a Research Topic to highlight the recent advances in neurovascular research for age-related cognitive impairment and neurodegenerative diseases.
Vascular mechanisms may contribute to the neurodegenerative changes in aging. Cerebral small vessel disease (SVD) or diffuse white matter hyperintensity (WMH) represent a diverse range of pathological changes that affect capillaries, small arteries, and small veins in the brain with vascular contributions to cognitive impairment. Such cerebrovascular abnormalities are often related to lacunar infarcts, microbleeds, microinfarcts, silent strokes, enlarged perivascular spaces, leukoaraiosis, cortical atrophy and cognitive impairment. However, apart from risk containment, efforts to prevent or to treat SVD are ineffective. Much remains to be learned about the cellular and molecular causes of SVD, regional vulnerability, and SVD progression over time.
It has been reported that one in three people will have a clinical stroke during their lifetime. Since cognitive deterioration develops in an estimated 30% of post-stroke patients; it is clear that the effects of this will have an enormous impact on public health. Traumatic brain injury (TBI) is another significant public health problem, which is defined as traumatically induced physiological and functional disruption of the brain. TBI is often associated with both acute (e.g. loss of consciousness) and long-term consequences, such as development of chronic traumatic encephalopathy (CTE), resulting in cognitive impairment.
In this Research Topic, we aim to gather recent research to better understand vascular contributions to age-related neurodegenerative diseases and cognitive impairment. We also aim to promote research exchange across different fields (e.g. imaging, molecular biology, pathology, clinical symptom monitoring and treatments). This is an exciting time in neurovascular and aging research and we hope to provide a comprehensive collection to cover the latest advances with a wide range of cross-disciplinary topics. Therefore, we welcome submissions of Original Research, Reviews, Mini-Reviews, Methods and Brief Research Reports on the following topics:
• Vascular anatomy studies of the brain: macro to microvasculature;
• Vascular physiology and neurovascular coupling;
• Vascular contributions to cognitive impairment: hypertension, SVD, WMH etc.;
• Advanced neurovascular imaging techniques in aging, stroke and cognitive impairment;
• Stroke and traumatic brain injury (TBI) and cognitive impairment;
• Therapeutic approaches and strategies for small and large vessel diseases.
Frontiers has provided sponsorship for the conference, the 10th Annual Meeting of ISNVD in 2020. The resulting Research Topic will be comprised of papers based on the talks given at the conference. This Research Topic collection is also open to the public submissions that fit the above thematic topics.
Keywords: Aging, cognitive impairment, vascular dementia, Alzheimer disease, stroke, ApoE, hypertension, diabetes, imaging, MRI, arterial and venous abnormalities
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.