Research Topic

Non-Pharmacologic Sustained Endothelial Shear Stress: An Evolving Clinical Paradigm

About this Research Topic

Flow mediated dilatation is a standard for acute assessment of endothelial function acting through induced increased blood flow after tourniquet release of an extremity. This creates shear stress to the endothelium which causes release of nitric oxide (NO) and other vasodilator mediators into the circulation with a usual duration of action of 8-10 minutes. In contrast, aerobic exercise promotes sustained shear stress that leads to long-lasting, NO bioavailability and health benefits. However, only about 30% of adults meet aerobic exercise recommended guidelines and are physically inactive. This poses a high risk for premature mortality and major non-communicable diseases and is associated with long periods of reduced shear stress. Noninvasive means and effects of sustained endothelial shear stress that are independent of physical activity will be the focus of this review.

The goal of this Research Topic is to put forth means and effects of producing sustained endothelial shear stress independent of physical activity in healthy humans and diseased patients. The means can be divided into 1) interventions to increase pulsatile shear stress by addition of pulses into circulation 2) interventions to increase laminar shear. We will explore various methods to induce the aforementioned in cells, animal models and human subjects, and signaling pathways which lead to the beneficial effects. The intermediate- and long-term effectiveness of sustained shear stress needs to be rigorously assessed.

Scope and information for Authors
- Preclinical and clinical comparisons between pulsatile and laminar endothelial shear stress.
- Sustained shear stress for management of various cardiovascular conditions including; heart failure, cardiomyopathy, and others.
- Pulsatile shear stress in management of respiratory conditions
- Pulsatile shear stress in management of diabetes
- Sustained shear stress during and after ischemia reperfusion injury
- Sustained shear stress in the management of chronic pain
- Sustained shear stress for hastening recovery from exercise and skeletal muscle injury
- Sustained shear stress in neurological diseases.

Topic Editor Dr. José Antonio Adams is a Co-Inventor of Respiband Plus and of a Computerized Algorithm for the Detection of Valid Pulse Oximeter Waveforms. He and Topic Editor Dr. Marvin A Sackner co-invented Gentle Jogger. Dr. Sackner is a Co-Founder and President of Sackner Wellness Products LLC (Miami, FL, USA). He has a number of patents, both joint and individual. Topic Editor Dr. Alfredo Martínez Ramírez has declared no competing interests with regards to the Research Topic subject.  


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Flow mediated dilatation is a standard for acute assessment of endothelial function acting through induced increased blood flow after tourniquet release of an extremity. This creates shear stress to the endothelium which causes release of nitric oxide (NO) and other vasodilator mediators into the circulation with a usual duration of action of 8-10 minutes. In contrast, aerobic exercise promotes sustained shear stress that leads to long-lasting, NO bioavailability and health benefits. However, only about 30% of adults meet aerobic exercise recommended guidelines and are physically inactive. This poses a high risk for premature mortality and major non-communicable diseases and is associated with long periods of reduced shear stress. Noninvasive means and effects of sustained endothelial shear stress that are independent of physical activity will be the focus of this review.

The goal of this Research Topic is to put forth means and effects of producing sustained endothelial shear stress independent of physical activity in healthy humans and diseased patients. The means can be divided into 1) interventions to increase pulsatile shear stress by addition of pulses into circulation 2) interventions to increase laminar shear. We will explore various methods to induce the aforementioned in cells, animal models and human subjects, and signaling pathways which lead to the beneficial effects. The intermediate- and long-term effectiveness of sustained shear stress needs to be rigorously assessed.

Scope and information for Authors
- Preclinical and clinical comparisons between pulsatile and laminar endothelial shear stress.
- Sustained shear stress for management of various cardiovascular conditions including; heart failure, cardiomyopathy, and others.
- Pulsatile shear stress in management of respiratory conditions
- Pulsatile shear stress in management of diabetes
- Sustained shear stress during and after ischemia reperfusion injury
- Sustained shear stress in the management of chronic pain
- Sustained shear stress for hastening recovery from exercise and skeletal muscle injury
- Sustained shear stress in neurological diseases.

Topic Editor Dr. José Antonio Adams is a Co-Inventor of Respiband Plus and of a Computerized Algorithm for the Detection of Valid Pulse Oximeter Waveforms. He and Topic Editor Dr. Marvin A Sackner co-invented Gentle Jogger. Dr. Sackner is a Co-Founder and President of Sackner Wellness Products LLC (Miami, FL, USA). He has a number of patents, both joint and individual. Topic Editor Dr. Alfredo Martínez Ramírez has declared no competing interests with regards to the Research Topic subject.  


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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