Research Topic

Angiogenesis and Immune System: Two Players in Cancer Field in the Era of Immunotherapy

About this Research Topic

The formation of new blood vessels from pre-existing vasculature (angiogenesis) and the infiltration of the immune cells have a critical role in the tumor microenvironment. Typically, the inflammatory process and the angiogenic switch are tightly connected during tumor onset, progression, and evolution. Moreover, the immunoediting processes within the tumor microenvironment are intrinsically devoted to modulate/reduce the specific and innate immune responses and to foster angiogenesis.

Anti-angiogenic approaches have been proposed to starve the tumor and nowadays vessel disruption and normalization represent the strategies for future therapies. On the other hand, in the last decade, different immunotherapeutic approaches emerged (i.e. antibodies, immunocytokines, CAR-T cells) to restore the anti-cancer activity of the immune system and to direct immune effectors against malignant cells and stromal components.

In this context, a state of the art discussion and new findings covering the “angio-immuno side” of cancer represent an extremely interesting and translational subject. We welcome submissions of Original Research and Review articles focusing on, but not limited to, the following subtopics:

1) New players, targets or mechanisms linking together angiogenesis and immune system in cancer.
2) Cancer modulation of immune system and angiogenesis.
3) Therapeutic approaches that impact angiogenesis and the immune system in cancer.
4) Immunotherapy effect on angiogenesis.
5) Impact of anti-angiogenic/vascular normalization approaches on immune system evolution.


Keywords: angiogenesis, immunotherapy, tumor hypoxia, immune checkpoint inhibitors, endothelial cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The formation of new blood vessels from pre-existing vasculature (angiogenesis) and the infiltration of the immune cells have a critical role in the tumor microenvironment. Typically, the inflammatory process and the angiogenic switch are tightly connected during tumor onset, progression, and evolution. Moreover, the immunoediting processes within the tumor microenvironment are intrinsically devoted to modulate/reduce the specific and innate immune responses and to foster angiogenesis.

Anti-angiogenic approaches have been proposed to starve the tumor and nowadays vessel disruption and normalization represent the strategies for future therapies. On the other hand, in the last decade, different immunotherapeutic approaches emerged (i.e. antibodies, immunocytokines, CAR-T cells) to restore the anti-cancer activity of the immune system and to direct immune effectors against malignant cells and stromal components.

In this context, a state of the art discussion and new findings covering the “angio-immuno side” of cancer represent an extremely interesting and translational subject. We welcome submissions of Original Research and Review articles focusing on, but not limited to, the following subtopics:

1) New players, targets or mechanisms linking together angiogenesis and immune system in cancer.
2) Cancer modulation of immune system and angiogenesis.
3) Therapeutic approaches that impact angiogenesis and the immune system in cancer.
4) Immunotherapy effect on angiogenesis.
5) Impact of anti-angiogenic/vascular normalization approaches on immune system evolution.


Keywords: angiogenesis, immunotherapy, tumor hypoxia, immune checkpoint inhibitors, endothelial cells


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

18 July 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

18 July 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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